PMID- 18173519
OWN - NLM
STAT- MEDLINE
DCOM- 20080312
LR  - 20191210
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 46
IP  - 12
DP  - 2007 Dec
TI  - Are age-specific high serum IgE levels associated with worse symptomatology in 
      children with atopic dermatitis?
PG  - 1258-62
LID - 10.1111/j.1365-4632.2007.03407.x [doi]
AB  - BACKGROUND: Atopic dermatitis (AD) is a distressing disease associated with 
      excoriations, pruritus, sleep disturbance, and elevation of serum total 
      immunoglobulin E (IgE) levels. OBJECTIVE: To evaluate whether serum IgE levels 
      correlate with the symptomatology and plasma chemokine levels in children with 
      AD. METHODS: AD patients aged younger than 18 years were recruited from the 
      pediatric dermatology clinic of a university teaching hospital, and the AD 
      severity was evaluated using the SCORing Atopic Dermatitis (SCORAD) index. 
      Concentrations of serum total IgE, eosinophil count, and plasma AD-associated 
      chemokines [cutaneous T-cell-attracting cytokine (CTACK), thymus and 
      activation-regulated chemokine (TARC)] were measured. RESULTS: One hundred and 
      seventeen Chinese children with AD (64 boys and 53 girls), with an age (mean +/- 
      standard deviation) of 10.7 +/- 4.4 years, were recruited. Their overall SCORAD 
      index (mean +/- standard deviation) was 51.1 +/- 22.8. The total serum IgE level 
      divided by the age-specific upper limit (AE) correlated well with the extent and 
      intensity of AD, except for oozing/crusting, which was significant only in males. 
      There was a significant correlation between AE and pruritus or sleep loss only in 
      females. Levels of IgE, CTACK, and TARC, and eosinophil count, differed 
      significantly between patients with mild, moderate, and severe disease. AE 
      correlated well with TARC (r = 0.50, P < 0.001) and eosinophil count (r = 0.41, P 
      < 0.001), but not with CTACK (r = 0.11, P = 0.270). The prediction of moderate to 
      severe eczema by AE gave an area under the receiver-operating characteristic 
      curve of 0.76 (95% confidence interval, 0.65-0.86; P = 0.004). An optimum 
      positive predictive value of 94.2% was achieved with a cut-off point of AE of 
      2.95, sensitivity of 75.0%, and specificity of 66.7%. CONCLUSION: AE correlates 
      significantly with various objective clinical scores and chemokine markers of AD, 
      and is a useful indicator for predicting moderate to severe AD in children.
FAU - Hon, Kam-Lun Ellis
AU  - Hon KL
AD  - Department of Pediatrics, The Chinese University of Hong Kong, Prince of Wales 
      Hospital, Shatin, Hong Kong, China. ehon@hotmail.com
FAU - Lam, Man-Ching Adrian
AU  - Lam MC
FAU - Leung, Ting-Fan
AU  - Leung TF
FAU - Wong, Kin-Yee
AU  - Wong KY
FAU - Chow, Chung-Mo
AU  - Chow CM
FAU - Fok, Tai-Fai
AU  - Fok TF
FAU - Ng, Pak-Cheung
AU  - Ng PC
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL17)
RN  - 0 (Chemokine CCL27)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Biomarkers/blood
MH  - Chemokine CCL17/blood
MH  - Chemokine CCL27/blood
MH  - Child
MH  - Dermatitis, Atopic/*blood/complications/pathology
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Immunoassay
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Predictive Value of Tests
MH  - Pruritus/etiology
MH  - ROC Curve
MH  - Severity of Illness Index
MH  - Skin/*pathology
MH  - Sleep Initiation and Maintenance Disorders/etiology
MH  - Statistics, Nonparametric
EDAT- 2008/01/05 09:00
MHDA- 2008/03/13 09:00
CRDT- 2008/01/05 09:00
PHST- 2008/01/05 09:00 [pubmed]
PHST- 2008/03/13 09:00 [medline]
PHST- 2008/01/05 09:00 [entrez]
AID - IJD3407 [pii]
AID - 10.1111/j.1365-4632.2007.03407.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2007 Dec;46(12):1258-62. doi: 10.1111/j.1365-4632.2007.03407.x.