PMID- 18173611
OWN - NLM
STAT- MEDLINE
DCOM- 20080407
LR  - 20181201
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 47
IP  - 1
DP  - 2008 Jan
TI  - Leflunomide in subacute cutaneous lupus erythematosus - two sides of a coin.
PG  - 83-6
LID - 10.1111/j.1365-4632.2007.03333.x [doi]
AB  - BACKGROUND: Subacute cutaneous lupus erythematosus (SCLE), a distinct clinical 
      subset of lupus erythematosus, remains a therapeutic challenge, especially in 
      cases resistant to topical and standard systemic therapy. Leflunomide, a novel 
      antirheumatic drug, has shown efficacy in the treatment of systemic lupus 
      erythematosus in pilot studies. METHODS: We report two patients with SCLE who 
      demonstrated the spectrum of possible clinical responses to leflunomide therapy. 
      RESULTS: One patient experienced a complete clinical remission of symptoms, 
      whereas the other developed a massive skin reaction which was distinctly related 
      to the commencement of leflunomide therapy. CONCLUSION: To our knowledge, this is 
      the first time that remission and deterioration of SCLE by leflunomide therapy 
      have been described.
FAU - Suess, Anke
AU  - Suess A
AD  - Department of Dermatology, University of Leipzig, Leipzig, Germany. 
      anke.suess@medizin.uni-leipzig.de
FAU - Sticherling, Michael
AU  - Sticherling M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Isoxazoles)
RN  - G162GK9U4W (Leflunomide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antirheumatic Agents/*administration & dosage/adverse effects
MH  - Diagnosis, Differential
MH  - Drug Eruptions/diagnosis/*etiology
MH  - Enzyme Inhibitors/*administration & dosage/adverse effects
MH  - Erythema Multiforme/*chemically induced/diagnosis
MH  - Female
MH  - Fluorescent Antibody Technique, Direct
MH  - Humans
MH  - Isoxazoles/*administration & dosage/adverse effects
MH  - Leflunomide
MH  - Lupus Erythematosus, Cutaneous/*chemically induced/diagnosis/*drug therapy
MH  - Male
MH  - Skin/pathology
EDAT- 2008/01/05 09:00
MHDA- 2008/04/09 09:00
CRDT- 2008/01/05 09:00
PHST- 2008/01/05 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2008/01/05 09:00 [entrez]
AID - IJD3333 [pii]
AID - 10.1111/j.1365-4632.2007.03333.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2008 Jan;47(1):83-6. doi: 10.1111/j.1365-4632.2007.03333.x.