PMID- 18173726
OWN - NLM
STAT- MEDLINE
DCOM- 20080327
LR  - 20080104
IS  - 0031-8655 (Print)
IS  - 0031-8655 (Linking)
VI  - 84
IP  - 1
DP  - 2008 Jan-Feb
TI  - Effect of X-radiation on lipid peroxidation and antioxidant systems in rats 
      treated with saponin-containing compounds.
PG  - 236-42
LID - 10.1111/j.1751-1097.2007.00240.x [doi]
AB  - The aim of this study was to investigate the effect of three saponin-containing 
      plant species extracts (Aesculuc hippocastanum L. seed extract [AHE], Medicago 
      sativa L. extract [MSE] and Spinacia oleracea L. extract [SOE]) on lipid 
      peroxidation and on antioxidant systems in rats exposed to X-rays (XR). The rats 
      were divided into three categories. The first category served as controls and 
      received only a standard diet. The second category served as the radiation group 
      and received 5 and 10 Gy XR dose. The third category (XR+extract-treated) 
      received plant extracts (25.0 or 50.0 mg kg(-1) live weight) and 5 or 10 Gy XR 
      dose. Blood samples were analyzed for their content of malondialdehyde (MDA), 
      reduced glutathione (GSH), plasma vitamin C, beta-carotene and retinol. In 
      animals receiving XR, the plasma MDA (P < 0.001) value significantly increased 
      but the level of GSH (P < 0.01), vitamin C (P < 0.001), retinol and beta-carotene 
      (P < 0.001) decreased significantly with increasing XR doses. In the 
      XR+extract-treated groups, the concentrations of MDA increased significantly with 
      increasing radiation but their concentrations decreased significantly with 
      increasing extract concentrations. Plasma concentrations of GSH, beta-carotene, 
      retinol and vitamin C in XR+extract-treated groups decreased significantly with 
      increasing XR dose but their concentrations increased with increasing extract 
      doses. Further, comparison of blood samples of XR+extract-treated groups with 
      those from the control group showed that GSH, beta-carotene, retinol and vitamin 
      C values increased significantly but that MDA values decreased significantly. The 
      results showed that all extracts have enhanced the antioxidant status and 
      decreased the incidence of free radical-induced lipid peroxidation in blood 
      samples of rats exposed to XR. However, the antioxidant effect of 
      AHE-administered animals was more effective than that of MSE- and 
      SOE-administered whole-body XR rats. We conclude that the supplementation with 
      saponin-containing extracts may serve to reinforce the antioxidant systems, thus 
      having protective effect against cell damage by XR.
FAU - Yalinkilic, Omer
AU  - Yalinkilic O
AD  - Kumluca Anatolian Vocation High School, Kumluca, Antalya, Turkey.
FAU - Enginar, Huseyin
AU  - Enginar H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Photochem Photobiol
JT  - Photochemistry and photobiology
JID - 0376425
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 0 (Saponins)
SB  - IM
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Lipid Peroxidation/*drug effects/*radiation effects
MH  - Male
MH  - Plant Extracts/chemistry/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Sapindus/chemistry
MH  - Saponins/*pharmacology
MH  - Seeds/chemistry
EDAT- 2008/01/05 09:00
MHDA- 2008/03/28 09:00
CRDT- 2008/01/05 09:00
PHST- 2008/01/05 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2008/01/05 09:00 [entrez]
AID - PHP240 [pii]
AID - 10.1111/j.1751-1097.2007.00240.x [doi]
PST - ppublish
SO  - Photochem Photobiol. 2008 Jan-Feb;84(1):236-42. doi: 
      10.1111/j.1751-1097.2007.00240.x.