PMID- 18174685
OWN - NLM
STAT- MEDLINE
DCOM- 20080530
LR  - 20080221
IS  - 1421-9867 (Electronic)
IS  - 0012-2823 (Linking)
VI  - 76
IP  - 3-4
DP  - 2007
TI  - Combined pH-metry/impedance monitoring increases the diagnostic yield in patients 
      with atypical gastroesophageal reflux symptoms.
PG  - 223-8
LID - 10.1159/000112728 [doi]
AB  - BACKGROUND: Globus sensations, hoarseness and chronic cough are suggested to be 
      atypical manifestations of Gastroesophageal Reflux Disease (GERD). The aim of the 
      study was to investigate whether combined pH-metry and multichannel intraluminal 
      impedance monitoring increases the diagnostic yield. METHODS: 41 patients with 
      atypical GERD symptoms were included in the study. Globus sensation was the 
      dominant symptom in 23 patients (56.1%). The remaining 18 patients (43.9%) 
      complained mainly about hoarseness or chronic cough. All patients were examined 
      by endoscopy, dual-channel pH-metry and impedance monitoring off-therapy with 
      proton pump inhibitors (PPI). Diagnostic yield of the respective method was 
      determined. RESULTS: A total of 26 patients (63.4%) had pathological findings in 
      any method. The highest diagnostic yield was achieved by combined 24-h 
      pH-metry/impedance measurement (61.0%), followed by solely impedance measurement 
      (48.8%), distal pH-metry (29.3%), endoscopy (22.8%) and proximal pH-metry 
      (17.1%). All patients with a positive PPI-test and 25% of patients (5/20) with a 
      negative PPI-test had a pathological result in pH-metry/impedance. CONCLUSION: 
      Multichannel intraluminal impedance monitoring increases the diagnostic yield for 
      objective detection of atypical manifestation of GERD. Combined 24-h 
      pH-metry/impedance measurement has the best diagnostic yield for detection of 
      gastroesophageal reflux and has therefore the potential to represent a new 
      diagnostic gold standard.
FAU - Bajbouj, Monther
AU  - Bajbouj M
AD  - II. Medizinische Klinik und Poliklinik, Klinikum Rechts der Isar, Technische 
      Universitat Munchen, Munchen, Germany.
FAU - Becker, Valentin
AU  - Becker V
FAU - Neuber, Martin
AU  - Neuber M
FAU - Schmid, Roland M
AU  - Schmid RM
FAU - Meining, Alexander
AU  - Meining A
LA  - eng
PT  - Journal Article
DEP - 20071221
PL  - Switzerland
TA  - Digestion
JT  - Digestion
JID - 0150472
SB  - IM
CIN - Digestion. 2007;76(3-4):221-2. PMID: 18174684
MH  - Adult
MH  - Aged
MH  - Cough/etiology
MH  - Deglutition Disorders/etiology
MH  - Electric Impedance
MH  - *Esophageal pH Monitoring
MH  - Female
MH  - Gastroesophageal Reflux/complications/*diagnosis
MH  - Hoarseness/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2008/01/05 09:00
MHDA- 2008/05/31 09:00
CRDT- 2008/01/05 09:00
PHST- 2007/05/09 00:00 [received]
PHST- 2007/08/07 00:00 [accepted]
PHST- 2008/01/05 09:00 [pubmed]
PHST- 2008/05/31 09:00 [medline]
PHST- 2008/01/05 09:00 [entrez]
AID - 000112728 [pii]
AID - 10.1159/000112728 [doi]
PST - ppublish
SO  - Digestion. 2007;76(3-4):223-8. doi: 10.1159/000112728. Epub 2007 Dec 21.