PMID- 18174755
OWN - NLM
STAT- MEDLINE
DCOM- 20080319
LR  - 20220408
IS  - 1076-7460 (Print)
IS  - 1076-7460 (Linking)
VI  - 17
IP  - 1
DP  - 2008 Jan-Feb
TI  - High NT-proBNP is a strong predictor of outcome in elderly heart failure 
      patients.
PG  - 13-20
AB  - All patients older than 65 years (184 men; mean age, 78+/-0.8 years/181 women; 
      mean age, 82+/-0.6 years) seeking medical attention at the Lund University 
      Hospital Emergency Clinic during a 2-year period who had an N-terminal prohormone 
      brain natriuretic peptide (NT-proBNP) value >2000 pg/mL were followed up for 
      survival. Mortality in the entire population was 21% after 3 months, 35% after 1 
      year, and 40% after 2 years. Multivariate analysis indicated that the NT-proBNP 
      level and the New York Heart Association (NYHA) functional class were stronger 
      predictors of mortality than were echocardiographic estimation of left 
      ventricular ejection fraction or chest radiography. Patients who survived the 
      first year were younger, had higher systolic blood pressure, had lower plasma 
      creatinine, had lower inflammatory activity, and were treated with lower doses of 
      furosemide. The results indicate that in this population, NT-proBNP level 
      together with assessment of NYHA class gives the best prognostic information of 
      1-year mortality.
FAU - Andersson, Sven E
AU  - Andersson SE
AD  - Department of Emergency Medicine, Institute of Clinical Science, Lund University 
      Hospital, Lund, Sweden. sven.ea@telia.com
FAU - Edvinsson, Marie-Louise
AU  - Edvinsson ML
FAU - Bjork, Jonas
AU  - Bjork J
FAU - Edvinsson, Lars
AU  - Edvinsson L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Geriatr Cardiol
JT  - The American journal of geriatric cardiology
JID - 9215283
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 7LXU5N7ZO5 (Furosemide)
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/physiology
MH  - Female
MH  - Furosemide/therapeutic use
MH  - Health Status
MH  - Health Status Indicators
MH  - Heart Failure/drug therapy/mortality/*physiopathology
MH  - Humans
MH  - Male
MH  - *Natriuretic Peptide, Brain
MH  - *Peptide Fragments
MH  - Prognosis
MH  - Prospective Studies
MH  - Sickness Impact Profile
MH  - *Treatment Outcome
EDAT- 2008/01/05 09:00
MHDA- 2008/03/20 09:00
CRDT- 2008/01/05 09:00
PHST- 2008/01/05 09:00 [pubmed]
PHST- 2008/03/20 09:00 [medline]
PHST- 2008/01/05 09:00 [entrez]
AID - 10.1111/j.1076-7460.2007.06674.x [doi]
PST - ppublish
SO  - Am J Geriatr Cardiol. 2008 Jan-Feb;17(1):13-20. doi: 
      10.1111/j.1076-7460.2007.06674.x.