PMID- 18174946
OWN - NLM
STAT- MEDLINE
DCOM- 20080320
LR  - 20221207
IS  - 0091-6765 (Print)
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Linking)
VI  - 115 Suppl 1
IP  - Suppl 1
DP  - 2007 Dec
TI  - Xenoandrogenic activity in serum differs across European and Inuit populations.
PG  - 21-7
LID - 10.1289/ehp.9353 [doi]
AB  - BACKGROUND: Animal and in vitro studies have indicated that human male 
      reproductive disorders can arise as a result of disrupted androgen receptor (AR) 
      signalling by persistent organic pollutants (POPs). Our aim in the present study 
      was to compare serum xenoandrogenic activity between study groups with different 
      POP exposures and to evaluate correlations to the POP proxy markers 
      2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 
      1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE). METHODS: We determined 
      xenoandrogenic activity in the serum fraction containing the lipophilic POPs but 
      free of endogenous hormones. Adult male serum (n = 261) from Greenland, Sweden, 
      Warsaw (Poland), and Kharkiv (Ukraine) was analyzed. Xenoandrogenic activity was 
      determined as the effect of serum extract alone (XAR) and in the presence of the 
      synthetic AR agonist R1881 (XARcomp) on AR transactivated luciferase activity. 
      RESULTS: The study groups differed significantly with respect to XARcomp 
      activity, which was increased in the Inuits and decreased in the European study 
      groups; we observed no difference for XAR activity. We found the highest level of 
      the AR antagonist p,p'-DDE in Kharkiv, and accordingly, this study group showed 
      the highest percent of serum samples with decreased XARcomp activities. 
      Furthermore, the percentage of serum samples with decreased XARcomp activities 
      followed the p,p'-DDE serum level for the European study groups. No correlations 
      between serum XAR or XARcomp activities and the two POP markers were revealed. 
      CONCLUSIONS: The differences in XARcomp serum activity between the study groups 
      suggest differences in chemical exposure profiles, genetics, and/or lifestyle 
      factors.
FAU - Kruger, Tanja
AU  - Kruger T
AD  - Department of Environmental and Occupational Medicine, Institute of Public 
      Health, University of Aarhus, Aarhus, Denmark.
FAU - Hjelmborg, Philip S
AU  - Hjelmborg PS
FAU - Jonsson, Bo A G
AU  - Jonsson BA
FAU - Hagmar, Lars
AU  - Hagmar L
FAU - Giwercman, Aleksander
AU  - Giwercman A
FAU - Manicardi, Gian-Carlo
AU  - Manicardi GC
FAU - Bizzaro, Davide
AU  - Bizzaro D
FAU - Spano, Marcello
AU  - Spano M
FAU - Rignell-Hydbom, Anna
AU  - Rignell-Hydbom A
FAU - Pedersen, Henning S
AU  - Pedersen HS
FAU - Toft, Gunnar
AU  - Toft G
FAU - Bonde, Jens Peter
AU  - Bonde JP
FAU - Bonefeld-Jorgensen, Eva C
AU  - Bonefeld-Jorgensen EC
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Androgens)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Receptors, Androgen)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.13.12.- (Luciferases)
RN  - ZRU0C9E32O (2,4,5,2',4',5'-hexachlorobiphenyl)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Androgens/blood/toxicity
MH  - Dichlorodiphenyl Dichloroethylene/blood/*toxicity
MH  - Endocrine Disruptors/blood/*toxicity
MH  - Environmental Exposure/*adverse effects
MH  - Environmental Pollutants/blood/*toxicity
MH  - Europe
MH  - Humans
MH  - Inuit
MH  - Life Style
MH  - Luciferases/metabolism
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Receptors, Androgen/*drug effects/metabolism
MH  - Signal Transduction
MH  - White People
PMC - PMC2174397
OTO - NOTNLM
OT  - AR activity
OT  - CB-153
OT  - human serum
OT  - p,p'-DDE
OT  - polychlorinated biphenyls
EDAT- 2008/01/05 09:00
MHDA- 2008/03/21 09:00
PMCR- 2007/12/01
CRDT- 2008/01/05 09:00
PHST- 2006/05/22 00:00 [received]
PHST- 2006/12/04 00:00 [accepted]
PHST- 2008/01/05 09:00 [pubmed]
PHST- 2008/03/21 09:00 [medline]
PHST- 2008/01/05 09:00 [entrez]
PHST- 2007/12/01 00:00 [pmc-release]
AID - ehp0115s1-000021 [pii]
AID - 10.1289/ehp.9353 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2007 Dec;115 Suppl 1(Suppl 1):21-7. doi: 
      10.1289/ehp.9353.