PMID- 18177436
OWN - NLM
STAT- MEDLINE
DCOM- 20090731
LR  - 20161125
IS  - 1751-553X (Electronic)
IS  - 1751-5521 (Linking)
VI  - 31
IP  - 3
DP  - 2009 Jun
TI  - Multiple osteolytic bone lesions with high serum levels of interleukin-6 and CCL 
      chemokines in a patient with adult T cell leukemia.
PG  - 368-71
LID - 10.1111/j.1751-553X.2007.01014.x [doi]
AB  - A 37-year-old woman was diagnosed as having chronic adult T-cell leukemia (ATL) 
      of the skin by a skin biopsy and human T-cell leukemia virus type-1 serology at 
      our hospital in August 1992. The skin lesions of ATL were improved by treatment 
      with psoralen ultraviolet ray A. She complained of severe pain in her bilateral 
      forearms, hands and ankles, and X-ray examination in July 1999 revealed multiple 
      punched-out lesions of the extremities. Serum levels of parathyroid 
      hormone-related peptide, interleukin-1beta (IL-1beta), tumor necrosis 
      factor-alpha and total serum receptor activator of nuclear factor kappaB ligand 
      were not elevated. However, serum levels of IL-6, CCL2 monocyte chemoattractant 
      protein-1 (MCP-1), CCL3 [macrophage inflammatory protein-1alpha (MIP-1alpha)] and 
      CCL4 (MIP-1beta) were markedly elevated. Here, we have discussed the possible 
      mechanism underlying the onset of the osteolytic lesions.
FAU - Chiba, K
AU  - Chiba K
AD  - Department of Gastroenterology and Hematology, Hokkaido University Graduate 
      School of Medicine, Kita-ku, Sapporo, Japan.
FAU - Hashino, S
AU  - Hashino S
FAU - Izumiyama, K
AU  - Izumiyama K
FAU - Toyoshima, N
AU  - Toyoshima N
FAU - Suzuki, S
AU  - Suzuki S
FAU - Kurosawa, M
AU  - Kurosawa M
FAU - Asaka, M
AU  - Asaka M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20071220
PL  - England
TA  - Int J Lab Hematol
JT  - International journal of laboratory hematology
JID - 101300213
RN  - 0 (Chemokines)
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Adult
MH  - Chemokines/*blood
MH  - Chronic Disease
MH  - Fatal Outcome
MH  - Female
MH  - Humans
MH  - Interleukin-6/*blood
MH  - Leukemia-Lymphoma, Adult T-Cell/*blood/*complications/pathology
MH  - Osteolysis/*blood/diagnostic imaging/*etiology/pathology
MH  - Radiography
EDAT- 2008/01/08 09:00
MHDA- 2009/08/01 09:00
CRDT- 2008/01/08 09:00
PHST- 2008/01/08 09:00 [pubmed]
PHST- 2009/08/01 09:00 [medline]
PHST- 2008/01/08 09:00 [entrez]
AID - CLH1014 [pii]
AID - 10.1111/j.1751-553X.2007.01014.x [doi]
PST - ppublish
SO  - Int J Lab Hematol. 2009 Jun;31(3):368-71. doi: 10.1111/j.1751-553X.2007.01014.x. 
      Epub 2007 Dec 20.