PMID- 18177832
OWN - NLM
STAT- MEDLINE
DCOM- 20080527
LR  - 20081121
IS  - 1097-6868 (Electronic)
IS  - 0002-9378 (Linking)
VI  - 198
IP  - 4
DP  - 2008 Apr
TI  - No association between antepartum serologic and genital tract evidence of herpes 
      simplex virus-2 coinfection and perinatal HIV-1 transmission.
PG  - 399.e1-5
LID - 10.1016/j.ajog.2007.10.784 [doi]
AB  - OBJECTIVE: The purpose of this study was to assess the risk of perinatal HIV-1 
      transmission in women who are coinfected with herpes simplex virus-2 (HSV-2). 
      STUDY DESIGN: We performed a nested case-control study of 26 women whose HIV-1 
      was transmitted to their infants and 52 control subjects whose HIV-1 was not 
      transmitted. We assessed antepartum serologic evidence of HSV-2 by HSV-2 
      serostatus and genital tract evidence of HSV-2 by presence of HSV-2 DNA. RESULTS: 
      There was no significant association between antepartum serologic evidence of 
      HSV-2 coinfection and the risk of perinatal HIV-1 transmission. There was also no 
      association between antepartum genital tract evidence of HSV-2 coinfection and 
      risk of perinatal HIV-1 transmission. CONCLUSION: Women who were infected with 
      HIV-1 with antepartum serologic and genital tract evidence of HSV-2 coinfection 
      did not appear to have an increased risk of perinatal HIV-1 transmission. 
      However, further investigations are needed to assess HSV-2 reactivation and the 
      risk of perinatal HIV-1 transmission at the time of delivery.
FAU - Chen, Katherine T
AU  - Chen KT
AD  - Department of Obstetrics and Gynecology and Epidemiology, Columbia University, 
      New York, NY 10032, USA. ktc10@columbia.edu
FAU - Tuomala, Ruth E
AU  - Tuomala RE
FAU - Chu, Clara
AU  - Chu C
FAU - Huang, Meei-Li
AU  - Huang ML
FAU - Watts, D Heather
AU  - Watts DH
FAU - Zorrilla, Carmen D
AU  - Zorrilla CD
FAU - Paul, Mary
AU  - Paul M
FAU - Hershow, Ron
AU  - Hershow R
FAU - Larussa, Philip
AU  - Larussa P
LA  - eng
GR  - 1 U01 AI 050274-01/AI/NIAID NIH HHS/United States
GR  - 9U01 DA 015054/DA/NIDA NIH HHS/United States
GR  - N01 AI 085339/AI/NIAID NIH HHS/United States
GR  - RR000188/RR/NCRR NIH HHS/United States
GR  - RR000645/RR/NCRR NIH HHS/United States
GR  - SK12 HD01275/HD/NICHD NIH HHS/United States
GR  - U01 AI 034841/AI/NIAID NIH HHS/United States
GR  - U01 AI 034858/AI/NIAID NIH HHS/United States
GR  - U01 DA 015053/DA/NIDA NIH HHS/United States
GR  - U01 HD 036117/HD/NICHD NIH HHS/United States
GR  - U01 HD 041983/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080221
PL  - United States
TA  - Am J Obstet Gynecol
JT  - American journal of obstetrics and gynecology
JID - 0370476
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Comorbidity
MH  - Female
MH  - HIV Infections/*diagnosis/epidemiology/*transmission
MH  - HIV-1
MH  - Herpes Genitalis/*diagnosis/epidemiology/immunology
MH  - Herpesvirus 2, Human/*immunology
MH  - Humans
MH  - Infectious Disease Transmission, Vertical
MH  - Perinatal Care
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious
MH  - Pregnancy Outcome
MH  - Risk Factors
EDAT- 2008/01/08 09:00
MHDA- 2008/05/28 09:00
CRDT- 2008/01/08 09:00
PHST- 2007/05/14 00:00 [received]
PHST- 2007/08/07 00:00 [revised]
PHST- 2007/10/01 00:00 [accepted]
PHST- 2008/01/08 09:00 [pubmed]
PHST- 2008/05/28 09:00 [medline]
PHST- 2008/01/08 09:00 [entrez]
AID - S0002-9378(07)01702-4 [pii]
AID - 10.1016/j.ajog.2007.10.784 [doi]
PST - ppublish
SO  - Am J Obstet Gynecol. 2008 Apr;198(4):399.e1-5. doi: 10.1016/j.ajog.2007.10.784. 
      Epub 2008 Feb 21.