PMID- 18178120
OWN - NLM
STAT- MEDLINE
DCOM- 20080331
LR  - 20080201
IS  - 1297-9589 (Print)
IS  - 1297-9589 (Linking)
VI  - 36
IP  - 1
DP  - 2008 Jan
TI  - [Synchronous bilateral breast cancer: risk factors, diagnosis, histology and 
      treatment].
PG  - 35-44
LID - 10.1016/j.gyobfe.2007.09.021 [doi]
AB  - OBJECTIVE: Synchronous bilateral breast carcinoma (SBBC) is not uncommon. Women 
      with unilateral breast carcinoma are at increased risk for developing 
      contralateral disease. The purpose of this study was to evaluate risk factors, 
      diagnostic circumstances, histological characteristics and therapeutic methods 
      for SBBC. PATIENTS AND METHODS: Between July 1992 and May 2006, 62 patients with 
      SBBC were treated at Tenon hospital (Paris, France). Population was divided into 
      two sub-groups corresponding with two successive periods. Epidemiological 
      characteristics, diagnostic circumstances, therapeutic methods and histological 
      characteristics were analysed. RESULTS: Global incidence of SBBC during this 
      period was 2.6%. The patients presenting a CSBS had a family antecedent of breast 
      cancer in 23.7% of the cases. The most frequent situation associated a palpable 
      tumour and an infraclinic contralateral lesion (43.5%). MRI made diagnosis 
      possible in seven tumours. Among the patients 38.7% had a bilateral mastectomy 
      and 33.9% profited from the technique of the ganglion sentinel. The proportions 
      of invasive lobular carcinomas and the multifocal tumours were 17.7%. The tumours 
      had the same histological type in 78.3% of the cases and the expression of 
      oestrogen receptors was identical in 91.4% of the cases. DISCUSSION AND 
      CONCLUSION: The principal risk factors of CSBS are a family history of breast 
      cancer, the histological type lobular invasive and the multifocal character of 
      the first tumour. A conservative surgery is possible as well as the use of the 
      technique of the ganglion sentinel. The CSBS have histological similarities, 
      probably due to environmental factors.
FAU - Marpeau, O
AU  - Marpeau O
AD  - Service de gynecologie-obstetrique, hopital Tenon, AP-HP, CancerEst, universite 
      Pierre-et-Marie-Curie, Paris-VI, 4, rue de la Chine, 75020 Paris, France.
FAU - Ancel, P-Y
AU  - Ancel PY
FAU - Antoine, M
AU  - Antoine M
FAU - Uzan, S
AU  - Uzan S
FAU - Barranger, E
AU  - Barranger E
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - Cancers du sein bilateraux synchrones: facteurs de risque, diagnostic, 
      histologie, traitement.
DEP - 20080104
PL  - France
TA  - Gynecol Obstet Fertil
JT  - Gynecologie, obstetrique & fertilite
JID - 100936305
SB  - IM
MH  - Aged
MH  - Breast Neoplasms/*diagnosis/epidemiology/genetics/*surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Incidence
MH  - Mastectomy/*methods
MH  - Middle Aged
MH  - Neoplasms, Multiple Primary/*diagnosis/epidemiology/genetics/*surgery
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2008/01/08 09:00
MHDA- 2008/04/01 09:00
CRDT- 2008/01/08 09:00
PHST- 2007/07/12 00:00 [received]
PHST- 2007/09/19 00:00 [accepted]
PHST- 2008/01/08 09:00 [pubmed]
PHST- 2008/04/01 09:00 [medline]
PHST- 2008/01/08 09:00 [entrez]
AID - S1297-9589(07)00550-4 [pii]
AID - 10.1016/j.gyobfe.2007.09.021 [doi]
PST - ppublish
SO  - Gynecol Obstet Fertil. 2008 Jan;36(1):35-44. doi: 10.1016/j.gyobfe.2007.09.021. 
      Epub 2008 Jan 4.