PMID- 18178258
OWN - NLM
STAT- MEDLINE
DCOM- 20080703
LR  - 20080307
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 194
IP  - 1-2
DP  - 2008 Feb
TI  - A disease-specific fraction isolated from IVIG is essential for the 
      immunosuppressive effect of IVIG in experimental autoimmune myasthenia gravis.
PG  - 89-96
LID - 10.1016/j.jneuroim.2007.11.020 [doi]
AB  - Intravenous immunoglobulin (IVIG) treatment is beneficially used in autoimmune 
      disorders including myasthenia gravis (MG) although its mode of action and active 
      components are still not fully identified. In an attempt to isolate from IVIG a 
      disease-specific suppressive fraction, IVIG was passed on columns of IgG from 
      rats with experimental autoimmune MG (EAMG) or from MG patients. These 
      chromatographies resulted in depletion of the suppressive activity of IVIG on rat 
      EAMG whereas the minute amounts of IgG fractions eluted from the EAMG- or 
      MG-specific columns retained the immunosuppressive activity of IVIG. These 
      results demonstrate that a minor disease-specific immunoglobulin fraction present 
      in IVIG is essential for its suppressive activity.
FAU - Fuchs, Sara
AU  - Fuchs S
AD  - Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel. 
      sara.fuchs@weizmann.ac.il
FAU - Feferman, Tali
AU  - Feferman T
FAU - Meidler, Roberto
AU  - Meidler R
FAU - Margalit, Raanan
AU  - Margalit R
FAU - Sicsic, Camille
AU  - Sicsic C
FAU - Wang, Ningshan
AU  - Wang N
FAU - Zhu, Kai-Yun
AU  - Zhu KY
FAU - Brenner, Talma
AU  - Brenner T
FAU - Laub, Orgad
AU  - Laub O
FAU - Souroujon, Miriam C
AU  - Souroujon MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080221
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Autoantibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (anti-IgG)
RN  - 9007-81-2 (Freund's Adjuvant)
SB  - IM
MH  - Animals
MH  - Antibodies, Anti-Idiotypic/immunology/*isolation & purification/therapeutic use
MH  - Antibody Specificity
MH  - Autoantibodies/immunology
MH  - Chromatography, Affinity
MH  - Freund's Adjuvant/immunology
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - Immunoglobulins, Intravenous/chemistry/*therapeutic use
MH  - Immunosorbent Techniques
MH  - Immunosuppressive Agents/isolation & purification/*therapeutic use
MH  - Myasthenia Gravis/immunology
MH  - Myasthenia Gravis, Autoimmune, Experimental/immunology/*therapy
MH  - Rats
MH  - Species Specificity
EDAT- 2008/01/08 09:00
MHDA- 2008/07/04 09:00
CRDT- 2008/01/08 09:00
PHST- 2007/10/16 00:00 [received]
PHST- 2007/11/27 00:00 [revised]
PHST- 2007/11/28 00:00 [accepted]
PHST- 2008/01/08 09:00 [pubmed]
PHST- 2008/07/04 09:00 [medline]
PHST- 2008/01/08 09:00 [entrez]
AID - S0165-5728(07)00436-5 [pii]
AID - 10.1016/j.jneuroim.2007.11.020 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2008 Feb;194(1-2):89-96. doi: 10.1016/j.jneuroim.2007.11.020. 
      Epub 2008 Feb 21.