PMID- 18179647
OWN - NLM
STAT- MEDLINE
DCOM- 20080502
LR  - 20221207
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 71
IP  - 3
DP  - 2008 Mar
TI  - Allele and extended haplotype polymorphism of HLA-A, -C, -B, -DRB1 and -DQB1 loci 
      in Polish population and genetic affinities to other populations.
PG  - 193-205
LID - 10.1111/j.1399-0039.2007.00991.x [doi]
AB  - Human leukocyte antigen (HLA)-A, -C, -B, -DRB1 and -DQB1 alleles were typed in 
      200 Polish healthy volunteers recruited for stem cell donor registry, using 
      sequence-specific primer (SSP) and direct sequencing-based methods. Enhanced 
      Bayesian approach of expectation maximization algorithm provided by phase 
      platform was used for extended HLA haplotype inferences. The numbers of 
      identified alleles (four-digit resolution) were 23, 23, 44, 27 and 18 alleles in 
      HLA-A, -C, -B, -DRB1 and -DQB1 loci, respectively, of both northern and southern 
      European frequency characteristics. The most frequent extended haplotypes were 
      Cw*0701-B*0801-DRB1*0301-DQB1*0201 and Cw*0702-B*0702-DRB1*1501-DQB1*0602, found 
      in 25 and 23 copies, respectively, in 400 tested chromosomes. The extended 
      haplotype found in the Polish population with higher frequency than in other 
      European population was A*2501-Cw*1203-B*1801-DRB1*1501-DQB1*0602 (six copies) 
      and especially its class I fragment (14 copies). The neighbour-joining and 
      correspondence analyses showed Central and northern European genetic affinities 
      of Polish population. In most cases, the observed European allele and haplotype 
      gradients display smooth topography around Polish population. Poles along with 
      Western Slavs have their specific contribution in the demographic history of 
      Europe. Our results will intensify the use of population data in stem cell donor 
      search and can potentially improve current algorithms, facilitating selection of 
      acceptable donors for patients in need of stem cell transplant.
FAU - Nowak, J
AU  - Nowak J
AD  - Laboratory of Immunogenetics, Institute of Haematology and Transfusion Medicine, 
      Warsaw, Poland. szpik@ihit.waw.pl
FAU - Mika-Witkowska, R
AU  - Mika-Witkowska R
FAU - Polak, M
AU  - Polak M
FAU - Zajko, M
AU  - Zajko M
FAU - Rogatko-Koros, M
AU  - Rogatko-Koros M
FAU - Graczyk-Pol, E
AU  - Graczyk-Pol E
FAU - Lange, A
AU  - Lange A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080107
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
SB  - IM
MH  - Algorithms
MH  - Alleles
MH  - Ethnicity/genetics
MH  - Genetics, Population
MH  - HLA Antigens/*genetics
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/genetics
MH  - HLA-C Antigens/genetics
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Poland
MH  - *Polymorphism, Genetic
MH  - Registries
MH  - Stem Cells
MH  - Tissue and Organ Procurement
MH  - White People/genetics
EDAT- 2008/01/09 09:00
MHDA- 2008/05/03 09:00
CRDT- 2008/01/09 09:00
PHST- 2008/01/09 09:00 [pubmed]
PHST- 2008/05/03 09:00 [medline]
PHST- 2008/01/09 09:00 [entrez]
AID - TAN991 [pii]
AID - 10.1111/j.1399-0039.2007.00991.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2008 Mar;71(3):193-205. doi: 10.1111/j.1399-0039.2007.00991.x. 
      Epub 2008 Jan 7.