PMID- 18179755
OWN - NLM
STAT- MEDLINE
DCOM- 20080225
LR  - 20170214
IS  - 0394-6320 (Print)
IS  - 0394-6320 (Linking)
VI  - 20
IP  - 4
DP  - 2007 Oct-Dec
TI  - Vertical hepatitis C virus transmission is not related to mother-child class-1 
      HLA concordance.
PG  - 827-31
AB  - Mother-child human leukocyte antigen (HLA)diversity is protective for vertical 
      transmission of some viruses. The aim of this study is to evaluate the role of 
      mother-child HLA diversity on hepatitis C virus (HCV) vertical transmission. 
      Forty consecutive HCV infected and 46 consecutive control uninfected children 
      born to HCV-RNA positive mothers were evaluated for HLA class-1 type concordance 
      with their mothers. No significant difference in the degree of HLA concordance 
      was found between HCV infected and uninfected children both when A, B, C (p=0.30) 
      and when only A and B alleles were evaluated (p=0.59). Mother-infant HLA 
      concordance does not affect HCV vertical transmission.
FAU - Azzari, C
AU  - Azzari C
AD  - Department of Paediatrics, University of Florence, Anna Meyer Children's 
      Hospital, Florence, Italy. maurizio.demartino@unifi.it
FAU - Indolfi, G
AU  - Indolfi G
FAU - Betti, L
AU  - Betti L
FAU - Moriondo, M
AU  - Moriondo M
FAU - Massai, C
AU  - Massai C
FAU - Becciolini, L
AU  - Becciolini L
FAU - Bertelli, L
AU  - Bertelli L
FAU - Poggi, G M
AU  - Poggi GM
FAU - De Martino, M
AU  - De Martino M
FAU - Resti, M
AU  - Resti M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Immunopathol Pharmacol
JT  - International journal of immunopathology and pharmacology
JID - 8911335
RN  - 0 (HLA Antigens)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Antigenic Variation/genetics
MH  - Female
MH  - HLA Antigens/*genetics
MH  - *Hepacivirus
MH  - Hepatitis C, Chronic/congenital/*transmission/virology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Infant, Newborn
MH  - *Infectious Disease Transmission, Vertical
MH  - Pregnancy
MH  - RNA/biosynthesis/genetics
EDAT- 2008/01/09 09:00
MHDA- 2008/02/26 09:00
CRDT- 2008/01/09 09:00
PHST- 2008/01/09 09:00 [pubmed]
PHST- 2008/02/26 09:00 [medline]
PHST- 2008/01/09 09:00 [entrez]
AID - 19 [pii]
AID - 10.1177/039463200702000419 [doi]
PST - ppublish
SO  - Int J Immunopathol Pharmacol. 2007 Oct-Dec;20(4):827-31. doi: 
      10.1177/039463200702000419.