PMID- 18180399
OWN - NLM
STAT- MEDLINE
DCOM- 20080226
LR  - 20160726
IS  - 1524-4563 (Electronic)
IS  - 0194-911X (Linking)
VI  - 51
IP  - 2
DP  - 2008 Feb
TI  - Hyperresistinemia is associated with coexistence of hypertension and type 2 
      diabetes.
PG  - 534-9
LID - 10.1161/HYPERTENSIONAHA.107.103077 [doi]
AB  - Numerous studies have demonstrated that high blood pressure substantially 
      increases the risk of microvascular and macrovascular complications in patients 
      with type 2 diabetes mellitus (T2DM). Currently, we found that serum resistin, an 
      adipocyte- and monocyte-derived cytokine, was positively correlated with several 
      components of the metabolic syndrome, including hypertension in T2DM. To 
      investigate the association of resistin with an etiologic difference among 
      subjects with hypertension with T2DM, hypertension without T2DM, and normotensive 
      T2DM, we analyzed 210 subjects, including 91 with hypertension with T2DM, 55 with 
      hypertension without T2DM, and 64 with normotensive T2DM. Serum resistin level 
      was higher in subjects with hypertension with T2DM, followed by subjects with 
      normotensive T2DM and hypertension without T2DM, irrespective of antihypertensive 
      treatment status (20.9+/-17.6 and 14.0+/-8.9 versus 11.2+/-7.6 ng/mL, 
      respectively; P<0.01). Simple regression analysis revealed that resistin 
      positively correlated with blood pressure (systolic blood pressure: r=0.29, 
      P<0.01; diastolic blood pressure: r=0.21, P<0.05) and intima-media thickness 
      (r=0.27; P<0.05) in patients with T2DM but not in subjects with hypertension 
      without T2DM. Multiple regression analysis, adjusted for age, gender, body mass 
      index, fasting glucose, high-density lipoprotein cholesterol, white blood cell 
      counts, and glomerular filtration rate, further revealed that resistin was an 
      independent factor for high blood pressure in patients with T2DM (P<0.05). In 
      vitro gene expression analysis in human coronary endothelial cells revealed that 
      resistin induced fatty acid binding protein, a key molecule of insulin 
      resistance, diabetes, and atherosclerosis. These results suggest that 
      hyperresistinemia would contribute to the pathogenesis of hypertension in 
      patients with T2DM, significantly linked to vascular complications and 
      cardiovascular events.
FAU - Takata, Yasunori
AU  - Takata Y
AD  - Department of Molecular and Genetic Medicine, Ehime University Graduate School of 
      Medicine, Toon, Ehime 791-0295, Japan. ytakata@m.ehime-u.ac.jp
FAU - Osawa, Haruhiko
AU  - Osawa H
FAU - Kurata, Mie
AU  - Kurata M
FAU - Kurokawa, Maki
AU  - Kurokawa M
FAU - Yamauchi, Junko
AU  - Yamauchi J
FAU - Ochi, Masaaki
AU  - Ochi M
FAU - Nishida, Wataru
AU  - Nishida W
FAU - Okura, Takafumi
AU  - Okura T
FAU - Higaki, Jitsuo
AU  - Higaki J
FAU - Makino, Hideichi
AU  - Makino H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080107
PL  - United States
TA  - Hypertension
JT  - Hypertension (Dallas, Tex. : 1979)
JID - 7906255
RN  - 0 (Fatty Acid-Binding Proteins)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Resistin)
SB  - IM
MH  - Aged
MH  - Blood Pressure
MH  - Cells, Cultured
MH  - Coronary Vessels/metabolism
MH  - Diabetes Mellitus, Type 2/*blood/*complications
MH  - Diabetic Angiopathies/etiology
MH  - Endothelial Cells/metabolism
MH  - Fatty Acid-Binding Proteins/genetics/metabolism
MH  - Female
MH  - Gene Expression/drug effects
MH  - Humans
MH  - Hypertension/*etiology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Recombinant Proteins/pharmacology
MH  - Resistin/*blood/pharmacology
MH  - Risk Factors
EDAT- 2008/01/09 09:00
MHDA- 2008/02/27 09:00
CRDT- 2008/01/09 09:00
PHST- 2008/01/09 09:00 [pubmed]
PHST- 2008/02/27 09:00 [medline]
PHST- 2008/01/09 09:00 [entrez]
AID - HYPERTENSIONAHA.107.103077 [pii]
AID - 10.1161/HYPERTENSIONAHA.107.103077 [doi]
PST - ppublish
SO  - Hypertension. 2008 Feb;51(2):534-9. doi: 10.1161/HYPERTENSIONAHA.107.103077. Epub 
      2008 Jan 7.