PMID- 1818306
OWN - NLM
STAT- MEDLINE
DCOM- 19920715
LR  - 20061115
VI  - 33
IP  - 6
DP  - 1991
TI  - Platelet surface glycoprotein changes in patients with cerebral ischemia.
PG  - 497-9
AB  - In vitro abnormalities of platelet behaviour have been described in patients with 
      ischemic cerebrovascular disease (ICD) suggesting that changes in platelet 
      receptors and/or platelet a granules may occur in the circulation. We 
      investigated the frequency of such alterations in 95 patients that were studied 
      within a few days after acute stroke. Using specific antibodies to two intrinsic 
      plasma membrane glycoproteins (GPs), the GPIIb-IIIa complex and GPIV, and to 
      thrombospondin (TSP), a a-granular protein that becomes expressed on the platelet 
      surface upon activation, we were able to distinguish two groups of patients: 16 
      patients presented an increased concentration of TSP on their platelets 
      demonstrating in vivo platelet secretion. These patients could constitute a group 
      with increased risk of thrombosis. In contrast, 20 patients presented a decreased 
      concentration of GPIIb-IIIa and GPIV. This decrease in intrinsic plasma membrane 
      GPs was associated with a decrease in mean platelet volume and may suggest the 
      occurrence of platelet fragmentation in the circulation.
FAU - Legrand, C
AU  - Legrand C
AD  - INSERM U 150, Hopital Lariboisiere, Paris, France.
FAU - Woimant, F
AU  - Woimant F
FAU - Haguenau, M
AU  - Haguenau M
FAU - Caen, J
AU  - Caen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Nouv Rev Fr Hematol (1978)
JT  - Nouvelle revue francaise d'hematologie
JID - 7909092
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Platelet Membrane Glycoproteins)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Monoclonal
MH  - Brain Ischemia/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Membrane Glycoproteins/*metabolism
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
PST - ppublish
SO  - Nouv Rev Fr Hematol (1978). 1991;33(6):497-9.