PMID- 18184759
OWN - NLM
STAT- MEDLINE
DCOM- 20081031
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 294
IP  - 3
DP  - 2008 Mar
TI  - Effects of freshwater and saltwater adaptation and dietary salt on fluid 
      compartments, blood pressure, and venous capacitance in trout.
PG  - R1061-7
LID - 10.1152/ajpregu.00698.2007 [doi]
AB  - Trout are of interest in defining the relationship between fluid and salt balance 
      on cardiovascular function because they thrive in freshwater (FW; volume loading, 
      salt depleting), saltwater (SW; volume depleting, salt loading), and FW while fed 
      a high-salt diet (FW-HS; volume and salt loading). The effects of chronic (>2 wk) 
      adaptation to these three protocols on blood volume (51Cr red cell space), 
      extracellular fluid volume (99mTc-diethylene triaminepenta-acetic acid space), 
      arterial (dorsal aortic; P(DA)) and venous (ductus Cuvier; Pven) blood pressure, 
      mean circulatory filling pressure (zero-flow Pven), and vascular capacitance were 
      examined in the present study on unanesthetized rainbow trout. Blood volume, 
      extracellular fluid volume, P(DA), Pven, and mean circulatory filling pressure 
      progressively increased in the order SW < FW < FW-HS. Vascular capacitance in SW 
      fish appeared to be continuous with the capacitance curve of FW fish and reflect 
      a passive volume-dependent unloading of the venous system of FW fish. Vascular 
      capacitance curves for FW-HS fish were displaced upward and parallel to those of 
      FW fish, indicative of an active increase in unstressed blood volume without any 
      change in vascular compliance. These studies are the first in any vertebrate to 
      measure the relationship between fluid compartments and cardiovascular function 
      during independent manipulation of volume and salt balance, and they show that 
      volume, but not salt, balance is the primary determinant of blood pressure in 
      trout. They also present a new paradigm with which to investigate the relative 
      contributions of water and salt balance in cardiovascular homeostasis.
FAU - Olson, Kenneth R
AU  - Olson KR
AD  - Indiana University School of Medicine South Bend, 1234 Notre Dame Ave., South 
      Bend, IN 46617, USA. olson.1@nd.edu
FAU - Hoagland, Todd M
AU  - Hoagland TM
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20080109
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Sodium Chloride, Dietary)
SB  - IM
MH  - Adaptation, Physiological/*physiology
MH  - Animals
MH  - Aorta, Thoracic/physiology
MH  - Blood Pressure/drug effects/*physiology
MH  - Blood Volume/physiology
MH  - Body Fluid Compartments/drug effects/*physiology
MH  - Diet
MH  - *Fresh Water
MH  - Homeostasis/physiology
MH  - Oncorhynchus mykiss/*physiology
MH  - *Seawater
MH  - Sodium Chloride, Dietary/*pharmacology
MH  - Vascular Capacitance/drug effects/*physiology
MH  - Water-Electrolyte Balance/physiology
EDAT- 2008/01/11 09:00
MHDA- 2008/11/01 09:00
CRDT- 2008/01/11 09:00
PHST- 2008/01/11 09:00 [pubmed]
PHST- 2008/11/01 09:00 [medline]
PHST- 2008/01/11 09:00 [entrez]
AID - 00698.2007 [pii]
AID - 10.1152/ajpregu.00698.2007 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R1061-7. doi: 
      10.1152/ajpregu.00698.2007. Epub 2008 Jan 9.