PMID- 18184909
OWN - NLM
STAT- MEDLINE
DCOM- 20080318
LR  - 20161122
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1120
DP  - 2007 Dec
TI  - Gene expression during development of fetal and adult Leydig cells.
PG  - 16-35
LID - 10.1196/annals.1411.016 [doi]
AB  - In rats and mice, Leydig cells are formed as two morphologically and functionally 
      different generations. The first generation develops in utero, from 
      undifferentiated stem Leydig cells (SLCs) that differentiate into fetal Leydig 
      cells (FLCs). After birth, SLCs that may differ from the fetal SLCs undergo 
      lineage-specific commitment and give rise to adult Leydig cells (ALCs). The 
      intermediates of ALCs first become apparent by day 11 postpartum. These 
      first-appearing intermediates, progenitor Leydig cells (PLCs), are spindle shaped 
      and identifiable as steroidogenic because they express luteinizing hormone 
      receptor (LHR) and 3beta-hydroxysteroid dehydrogenase (3betaHSD). The next step 
      in the transition of PLCs to ALCs is the appearance of the immature Leydig cells 
      (ILCs), most commonly seen in the testis during days 28 to 56 postpartum. ILCs 
      have a more abundant smooth endoplasm reticulum (SER), the network of membranes 
      providing a scaffold for steroidogenic enzyme localization, compared to PLCs, but 
      are considered immature because they secrete higher levels of 5alpha-reduced 
      androgen than testosterone. ILCs undergo a final division before ALC 
      steroidogenic function matures by postnatal day 56. ALCs mark the point of 
      maximum differentiation, and at this stage, the Leydig cell secretes testosterone 
      at the highest rate. In this review, trends of gene expression during development 
      of the two Leydig-cell generations, and recent information from gene profiling by 
      microarray, are evaluated. The expression profiles are distinct, indicating that 
      FLCs and ALCs may originate from separate pools of stem cells.
FAU - Dong, Lei
AU  - Dong L
AD  - Department of Pathology, the 1st Affiliated Hospital of Wenzhou Medical College, 
      Zhejiang, 325000, China.
FAU - Jelinsky, Scott A
AU  - Jelinsky SA
FAU - Finger, Joshua N
AU  - Finger JN
FAU - Johnston, Daniel S
AU  - Johnston DS
FAU - Kopf, Gregory S
AU  - Kopf GS
FAU - Sottas, Chantal M
AU  - Sottas CM
FAU - Hardy, Matthew P
AU  - Hardy MP
FAU - Ge, Ren-Shan
AU  - Ge RS
LA  - eng
GR  - R01 AG030598/AG/NIA NIH HHS/United States
GR  - R01 AG030598-01/AG/NIA NIH HHS/United States
GR  - R01 HD050570/HD/NICHD NIH HHS/United States
GR  - R01 HD050570-01A2/HD/NICHD NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
SB  - IM
MH  - Adult Stem Cells/metabolism/physiology
MH  - Age Factors
MH  - Animals
MH  - Cell Differentiation/genetics
MH  - Cell Lineage/genetics
MH  - Embryo, Mammalian
MH  - Fetus/*metabolism
MH  - Gene Expression Profiling
MH  - *Gene Expression Regulation, Developmental
MH  - Leydig Cells/*metabolism/*physiology
MH  - Male
MH  - Models, Biological
MH  - Oligonucleotide Array Sequence Analysis
MH  - Rats
MH  - Stem Cells/metabolism
EDAT- 2008/01/11 09:00
MHDA- 2008/03/19 09:00
CRDT- 2008/01/11 09:00
PHST- 2008/01/11 09:00 [pubmed]
PHST- 2008/03/19 09:00 [medline]
PHST- 2008/01/11 09:00 [entrez]
AID - 1120/1/16 [pii]
AID - 10.1196/annals.1411.016 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2007 Dec;1120:16-35. doi: 10.1196/annals.1411.016.