PMID- 18185105
OWN - NLM
STAT- MEDLINE
DCOM- 20080324
LR  - 20080110
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 19
IP  - 2
DP  - 2008 Jan 22
TI  - Monocyte chemoattractant protein-1 immunoreactivity in sensory ganglia and 
      hindpaw after adjuvant injection.
PG  - 183-6
LID - 10.1097/WNR.0b013e3282f3c781 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1)/CCL2 is a member of the CC chemokine 
      family that exhibits potent chemotactic activity for monocytes/macrophages. In 
      the current study, the proportion of monocyte chemoattractant 
      protein-1-immunoreactive (IR) neurons in the dorsal root ganglion (DRG) of rats 
      was shown to increase markedly following adjuvant injection into the hindpaw. 
      MCP-1-IR axon terminals were not found in the spinal cord or hindpaw of control 
      or adjuvant-treated rats. Instead, the inflamed hindpaw dermis was infiltrated by 
      numerous MCP-1-IR inflammatory cells. Following adjuvant injection, the majority 
      of MCP-1-IR neurons in the DRG colocalized with IB4 binding. Our findings suggest 
      that peripheral tissue inflammation induces increased MCP-1 expression in DRG 
      neurons and this may be dependent upon glial cell line-derived neurotrophic 
      factor.
FAU - Jeon, Sang-Min
AU  - Jeon SM
AD  - Department of Anatomy, School of Medicine, Kyungpook National University 
      cDepartment of Anesthesiology and Pain Medicine, Kyungpook National University 
      Hospital, Daegu, South Korea.
FAU - Lee, Kyung-Min
AU  - Lee KM
FAU - Park, Eun-Sung
AU  - Park ES
FAU - Jeon, Young-Hoon
AU  - Jeon YH
FAU - Cho, Hee-Jung
AU  - Cho HJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Griffonia simplicifolia lectins)
RN  - 0 (Inflammation Mediators)
RN  - 0 (Plant Lectins)
RN  - 9007-81-2 (Freund's Adjuvant)
SB  - IM
MH  - Animals
MH  - Chemokine CCL2/immunology/*metabolism
MH  - Chemotaxis, Leukocyte/drug effects/*immunology
MH  - Freund's Adjuvant
MH  - Ganglia, Spinal/cytology/immunology/*metabolism
MH  - Glial Cell Line-Derived Neurotrophic Factor/immunology/metabolism
MH  - Hyperalgesia/chemically induced/metabolism/physiopathology
MH  - Inflammation/immunology/*metabolism/physiopathology
MH  - Inflammation Mediators
MH  - Macrophages/drug effects/immunology
MH  - Male
MH  - Neurons, Afferent/immunology/*metabolism
MH  - Peripheral Nervous System Diseases/immunology/*metabolism/physiopathology
MH  - Plant Lectins
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Skin/immunology/innervation/physiopathology
MH  - Up-Regulation/immunology
EDAT- 2008/01/11 09:00
MHDA- 2008/03/25 09:00
CRDT- 2008/01/11 09:00
PHST- 2008/01/11 09:00 [pubmed]
PHST- 2008/03/25 09:00 [medline]
PHST- 2008/01/11 09:00 [entrez]
AID - 00001756-200801220-00010 [pii]
AID - 10.1097/WNR.0b013e3282f3c781 [doi]
PST - ppublish
SO  - Neuroreport. 2008 Jan 22;19(2):183-6. doi: 10.1097/WNR.0b013e3282f3c781.