PMID- 18185919
OWN - NLM
STAT- MEDLINE
DCOM- 20080829
LR  - 20220330
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 197
IP  - 3
DP  - 2008 Apr
TI  - MDMA modifies active avoidance learning and recall in mice.
PG  - 391-400
LID - 10.1007/s00213-007-1045-z [doi]
AB  - RATIONALE: Several studies have suggested the existence of cognitive deficits 
      after repeated or high doses of 3,4-methylenedioxymethamphetamine (MDMA) in 
      humans and experimental animals. However, the extent of the impairments observed 
      in learning or memory tasks remains unclear. OBJECTIVE: The objective of this 
      study was to evaluate the effects of different dosing regimens of MDMA on the 
      ability of mice to learn and recall an active avoidance task. MATERIALS AND 
      METHODS: Animals were treated with MDMA (0, 1, 3, 10 and 30 mg/kg) under four 
      different experimental conditions, and active avoidance acquisition and recall 
      were evaluated. In experiments 1 and 2, MDMA was administered 1 h before 
      different active avoidance training sessions. In experiments 3 and 4, mice 
      received a repeated treatment with MDMA before or after active avoidance 
      training, respectively. Changes in presynaptic striatal dopamine transporter 
      (DAT) binding sites were evaluated at two different time points in animals 
      receiving a high dose of MDMA (30 mg/kg) or saline twice a day over 4 days. 
      RESULTS: MDMA administered before the active avoidance sessions interfered with 
      the acquisition and the execution of a previously learned task. A repeated 
      treatment with high doses of MDMA administered before training reduced 
      acquisition of active avoidance in mice, while pre-treatment with both high and 
      low doses of MDMA impaired recall of this task. A reduction in DAT binding was 
      observed 4 days but not 23 days after the last MDMA administration. CONCLUSIONS: 
      Acute MDMA modifies the acquisition and execution of active avoidance in mice, 
      while repeated pre-treatment with MDMA impairs acquisition and recall of this 
      task.
FAU - Trigo, Jose Manuel
AU  - Trigo JM
AD  - Laboratori de Neurofarmacologia, Departament de Ciencies Experimentals i de la 
      Salut, Universitat Pompeu Fabra, Barcelona, Spain.
FAU - Cabrero-Castel, Araceli
AU  - Cabrero-Castel A
FAU - Berrendero, Fernando
AU  - Berrendero F
FAU - Maldonado, Rafael
AU  - Maldonado R
FAU - Robledo, Patricia
AU  - Robledo P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080110
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
EIN - Psychopharmacology (Berl). 2008 Sep;200(1):151-3
MH  - Adrenergic Uptake Inhibitors/*pharmacology
MH  - Animals
MH  - Association Learning/drug effects
MH  - Avoidance Learning/*drug effects
MH  - Conditioning, Classical/*drug effects
MH  - Corpus Striatum/drug effects
MH  - Dopamine Plasma Membrane Transport Proteins/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Fear/drug effects
MH  - Male
MH  - Mental Recall/*drug effects
MH  - Mice
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Retention, Psychology/drug effects
EDAT- 2008/01/11 09:00
MHDA- 2008/08/30 09:00
CRDT- 2008/01/11 09:00
PHST- 2007/06/26 00:00 [received]
PHST- 2007/12/04 00:00 [accepted]
PHST- 2008/01/11 09:00 [pubmed]
PHST- 2008/08/30 09:00 [medline]
PHST- 2008/01/11 09:00 [entrez]
AID - 10.1007/s00213-007-1045-z [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2008 Apr;197(3):391-400. doi: 
      10.1007/s00213-007-1045-z. Epub 2008 Jan 10.