PMID- 18187037
OWN - NLM
STAT- MEDLINE
DCOM- 20080304
LR  - 20181113
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 367
IP  - 3
DP  - 2008 Mar 14
TI  - Forkhead transcription factors regulate expression of the chemokine receptor 
      CXCR4 in endothelial cells and CXCL12-induced cell migration.
PG  - 584-9
LID - 10.1016/j.bbrc.2007.12.183 [doi]
AB  - Foxc1 and Foxc2 transcription factors are required for vascular development. 
      However, the molecular mechanisms by which Foxc1 and Foxc2 control angiogenesis, 
      the growth of new blood vessels from pre-existing vessels and capillaries, remain 
      unknown. CXC chemokine ligand 12 (CXCL12) and its receptor, CXCR4, are critical 
      for the process of angiogenesis, including the migration and tube formation of 
      endothelial cells. Here we show that Foxc1 and Foxc2 directly induce CXCR4 
      expression by activating its promoter in endothelial cells. Furthermore, 
      Foxc1-deficient endothelial cells show a significant reduction in CXCR4 
      expression as well as CXCL12-stimulated migration. Taken together, these results 
      provide novel evidence that Foxc transcription factors are important regulators 
      of the chemotactic motility of endothelial cells through the induction of CXCR4 
      expression.
FAU - Hayashi, Hisaki
AU  - Hayashi H
AD  - Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt 
      University Medical Center, Nashville, TN 37232-6300, USA.
FAU - Kume, Tsutomu
AU  - Kume T
LA  - eng
GR  - HL74121/HL/NHLBI NIH HHS/United States
GR  - P01 HL067105-039002/HL/NHLBI NIH HHS/United States
GR  - R01 HL074121-04/HL/NHLBI NIH HHS/United States
GR  - P01 HL067105-049002/HL/NHLBI NIH HHS/United States
GR  - R01 HL074121/HL/NHLBI NIH HHS/United States
GR  - P01 HL067105-059002/HL/NHLBI NIH HHS/United States
GR  - HL67105/HL/NHLBI NIH HHS/United States
GR  - P01 HL067105-019002/HL/NHLBI NIH HHS/United States
GR  - R01 HL074121-02/HL/NHLBI NIH HHS/United States
GR  - R01 HL074121-01A1/HL/NHLBI NIH HHS/United States
GR  - R01 EY019484/EY/NEI NIH HHS/United States
GR  - P01 HL067105-029002/HL/NHLBI NIH HHS/United States
GR  - P01 HL067105/HL/NHLBI NIH HHS/United States
GR  - R01 HL074121-03/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080108
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (CXCR4 protein, mouse)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxc1 protein, mouse)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (mesenchyme fork head 1 protein)
SB  - IM
MH  - Animals
MH  - Cell Movement/*drug effects
MH  - Cells, Cultured
MH  - Chemokine CXCL12/pharmacology/*physiology
MH  - Endothelial Cells/*metabolism
MH  - Forkhead Transcription Factors/genetics/*physiology
MH  - Gene Expression Regulation/drug effects
MH  - Gene Transfer Techniques
MH  - Mice
MH  - Mice, Transgenic
MH  - Promoter Regions, Genetic/genetics
MH  - Receptors, CXCR4/genetics/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcriptional Activation/drug effects/genetics
PMC - PMC2265419
MID - NIHMS40119
EDAT- 2008/01/12 09:00
MHDA- 2008/03/05 09:00
PMCR- 2009/03/14
CRDT- 2008/01/12 09:00
PHST- 2007/12/30 00:00 [received]
PHST- 2007/12/30 00:00 [accepted]
PHST- 2008/01/12 09:00 [pubmed]
PHST- 2008/03/05 09:00 [medline]
PHST- 2008/01/12 09:00 [entrez]
PHST- 2009/03/14 00:00 [pmc-release]
AID - S0006-291X(08)00015-6 [pii]
AID - 10.1016/j.bbrc.2007.12.183 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2008 Mar 14;367(3):584-9. doi: 
      10.1016/j.bbrc.2007.12.183. Epub 2008 Jan 8.