PMID- 18189165 OWN - NLM STAT- MEDLINE DCOM- 20080327 LR - 20181113 IS - 1096-4657 (Electronic) IS - 0361-073X (Print) IS - 0361-073X (Linking) VI - 34 IP - 1 DP - 2008 Jan-Mar TI - Patterns of neurotrophin protein levels in male and female Fischer 344 rats from adulthood to senescence: how young is "young" and how old is "old"? PG - 13-26 LID - 10.1080/03610730701761908 [doi] AB - The current study assessed neurotrophin protein levels in male and female rat brain tissues at four different ages ranging from postpuberty to senescence. In both sexes nerve growth factor (NGF) increased, and brain-derived neurotrophic factor (BDNF) decreased, from 4 to 24 months of age. Using a slightly older age for the young group, or a slightly younger age for the aged group, had profound effects on whether age effects were realized. There were no sex differences in the pattern of change in neurotrophin levels across age, and neurotrophin levels did not correlate with estrogen levels in females or estrogen or testosterone levels in males. The current findings suggest that profound changes in neurotrophin protein levels can occur within only a few months time, and that these changes influence whether age-related neurotrophin alterations are realized. FAU - Bimonte-Nelson, Heather A AU - Bimonte-Nelson HA AD - Department of Psychology, Behavioral Neuroscience Division, Arizona State University, Tempe, Arizona 85287, USA. bimonte.nelson@asu.edu FAU - Granholm, Ann-Charlotte E AU - Granholm AC FAU - Nelson, Matthew E AU - Nelson ME FAU - Moore, Alfred B AU - Moore AB LA - eng GR - AG026137/AG/NIA NIH HHS/United States GR - AG10755/AG/NIA NIH HHS/United States GR - R01 AG010755/AG/NIA NIH HHS/United States GR - R01 AG010755-09/AG/NIA NIH HHS/United States GR - R03 AG026137/AG/NIA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Exp Aging Res JT - Experimental aging research JID - 7603335 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 3XMK78S47O (Testosterone) RN - 4TI98Z838E (Estradiol) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - Aging/*physiology MH - Analysis of Variance MH - Animals MH - Brain/*physiology MH - *Brain-Derived Neurotrophic Factor/analysis/genetics MH - Estradiol/blood MH - Female MH - In Situ Hybridization MH - Male MH - *Nerve Growth Factor/analysis/genetics MH - Rats MH - Rats, Inbred F344 MH - Sex Factors MH - Testosterone/blood PMC - PMC2692474 MID - NIHMS105239 EDAT- 2008/01/15 09:00 MHDA- 2008/03/28 09:00 PMCR- 2009/06/08 CRDT- 2008/01/15 09:00 PHST- 2008/01/15 09:00 [pubmed] PHST- 2008/03/28 09:00 [medline] PHST- 2008/01/15 09:00 [entrez] PHST- 2009/06/08 00:00 [pmc-release] AID - 789519642 [pii] AID - 10.1080/03610730701761908 [doi] PST - ppublish SO - Exp Aging Res. 2008 Jan-Mar;34(1):13-26. doi: 10.1080/03610730701761908.