PMID- 18189427 OWN - NLM STAT- MEDLINE DCOM- 20080402 LR - 20131121 IS - 0743-7463 (Print) IS - 0743-7463 (Linking) VI - 24 IP - 3 DP - 2008 Feb 5 TI - Patterning of magnetic nanobeads on surfaces by poly(dimethylsiloxane) stamps. PG - 888-93 LID - 10.1021/la7018956 [doi] AB - Poly(dimethylsiloxane) (PDMS) stamps are widely used in soft lithographic methods. They are powerful tools for obtaining structures of soft material in the micrometer to nanometer range by printing techniques. In this contribution, a new application of h-PDMS stamps for nanobead deposition is introduced. Magnetite-polysaccharide particles of an average diameter of 150 nm are used. They can be biologically functionalized by attaching various molecular groups. Deposition of these particles on a carrier substrate results in well-reproducible structures. This is achieved by means of PDMS stamps with different patterns using a microfluidic approach on one hand and a printing approach on the other hand. Furthermore, magnetic substrates with particular domain structures have been used. The beads can then be arranged in rather complicated but well-defined geometrical structures along the domain walls. The magnetic interaction considerably increases the adhesion of the beads to the carrier substrate. All involved materials are biocompatible. Thus the setup can be used in cell culture experiments in order to investigate influences of different particle-bound proteins and particle patterns on cell growth and vitality. FAU - Issle, Juliane AU - Issle J AD - University of Saarland, Institute of Experimental Physics, P.O. Box 151 150, 66041 Saarbruecken, Germany. j.issle@mx.uni-saarland.de FAU - Pla-Roca, Mateu AU - Pla-Roca M FAU - Martinez, Elena AU - Martinez E FAU - Hartmann, Uwe AU - Hartmann U LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20080112 PL - United States TA - Langmuir JT - Langmuir : the ACS journal of surfaces and colloids JID - 9882736 RN - 0 (Coated Materials, Biocompatible) RN - 0 (Dimethylpolysiloxanes) RN - 0 (Silicones) RN - 63148-62-9 (baysilon) RN - XM0M87F357 (Ferrosoferric Oxide) SB - IM MH - Cell Line MH - Coated Materials, Biocompatible/chemistry MH - Dimethylpolysiloxanes/*chemistry MH - Ferrosoferric Oxide/*chemistry MH - Humans MH - Magnetics MH - Metal Nanoparticles/*chemistry/ultrastructure MH - Microfluidic Analytical Techniques MH - Microscopy, Atomic Force MH - Microscopy, Electron, Transmission MH - Nanotechnology MH - Osteoblasts/cytology MH - Silicones/*chemistry MH - Surface Properties EDAT- 2008/01/15 09:00 MHDA- 2008/04/03 09:00 CRDT- 2008/01/15 09:00 PHST- 2008/01/15 09:00 [pubmed] PHST- 2008/04/03 09:00 [medline] PHST- 2008/01/15 09:00 [entrez] AID - 10.1021/la7018956 [doi] PST - ppublish SO - Langmuir. 2008 Feb 5;24(3):888-93. doi: 10.1021/la7018956. Epub 2008 Jan 12.