PMID- 18191725
OWN - NLM
STAT- MEDLINE
DCOM- 20080305
LR  - 20211203
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 12
DP  - 2007 Dec
TI  - Immunopathogenesis of dengue hemorrhagic fever and shock syndrome: role of TAP 
      and HPA gene polymorphism.
PG  - 973-9
LID - 10.1016/j.humimm.2007.09.007 [doi]
AB  - Clinical outcomes of dengue infection such as dengue fever (DF), dengue 
      hemorrhagic fever (DHF), and dengue shock syndrome (DSS) could be attributed to 
      host genetic factors. The transporters associated with antigen processing (TAP) 
      genes are polymorphic genes located in the human leukocyte antigen (HLA) class II 
      region and are essentially involved in class I antigen presentation. Therefore, 
      these genes might grant susceptibility to severe dengue infection. Hence, the aim 
      of the study was to type the TAP1 gene (using amplification refraction mutation 
      system [ARMS] polymerase chain reaction [PCR]) and HPA1 and HPA2 gene 
      polymorphism (by PCR-sequence specific primers) in different clinical spectrums 
      of dengue infection. The study included 100 controls and 91 DF, 75 DHF, and 32 
      DSS patients. The results revealed that the frequencies of valine at TAP1 333 and 
      HPA 1b at HPA1 were increased among DHF and DSS, respectively, in comparison to 
      controls (p <0.05). The frequency of genotype TAP1 333 ILE/VAL (61.3%) was 
      significantly higher in DHF compared with control (37%, p = 0.005) or DF (38.9%, 
      p = 0.007) patients. A significantly greater proportion of DHF patients 
      demonstrated HPA1a/1a and HPA 2a/2b genotypes than DF patients. DSS patients were 
      more likely to be heterozygous at HPA1 than DHF (OR = 4.75, p = 0.003). A 
      positive correlation existed between TAP1 333 and HPA1 in DHF (p = 0.017, r = 
      0.229). This first report on TAP and HPA gene polymorphism in dengue suggested 
      that the heterozygous pattern at the TAP1 333 locus and HPA1a/1a and HPA2a/2b 
      genotypes confer susceptibility to DHF and the HPA1a/1b genotype was determined 
      to be a genetic risk factor for DSS.
FAU - Soundravally, R
AU  - Soundravally R
AD  - Department of Molecular Biology and Bioinformatics, Vector Control Research 
      Centre, Pondicherry, India.
FAU - Hoti, S L
AU  - Hoti SL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071023
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (2a alloantigen, human)
RN  - 0 (2b alloantigen, human)
RN  - 0 (ATP Binding Cassette Transporter, Subfamily B, Member 2)
RN  - 0 (ATP-Binding Cassette Transporters)
RN  - 0 (Antigens, Human Platelet)
RN  - 0 (ITGB3 protein, human)
RN  - 0 (Integrin beta3)
RN  - 0 (TAP1 protein, human)
RN  - 0 (human platelet antigen 1b)
SB  - IM
MH  - ATP Binding Cassette Transporter, Subfamily B, Member 2
MH  - ATP-Binding Cassette Transporters/*genetics
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Antigens, Human Platelet/*genetics/immunology/metabolism
MH  - Dengue Virus/isolation & purification
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Integrin beta3
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Polymorphism, Genetic
MH  - Severe Dengue/genetics/immunology/*physiopathology/virology
EDAT- 2008/01/15 09:00
MHDA- 2008/03/06 09:00
CRDT- 2008/01/15 09:00
PHST- 2007/05/04 00:00 [received]
PHST- 2007/08/27 00:00 [revised]
PHST- 2007/09/20 00:00 [accepted]
PHST- 2008/01/15 09:00 [pubmed]
PHST- 2008/03/06 09:00 [medline]
PHST- 2008/01/15 09:00 [entrez]
AID - S0198-8859(07)00451-X [pii]
AID - 10.1016/j.humimm.2007.09.007 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Dec;68(12):973-9. doi: 10.1016/j.humimm.2007.09.007. Epub 2007 
      Oct 23.