PMID- 18191729
OWN - NLM
STAT- MEDLINE
DCOM- 20080305
LR  - 20080114
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 12
DP  - 2007 Dec
TI  - Generation of HLA-B*1516/B*1567/B*1595 and B*1517 alleles (B15 specific group) by 
      transpecies evolution.
PG  - 1001-8
LID - 10.1016/j.humimm.2007.10.010 [doi]
AB  - The generation of the human leukocyte antigen (HLA)-B*1516, B*1517, B*1567, and 
      B*1595 alleles has been analyzed using exon 1, intron 1, exon 2, intron 2, and 
      exon 3 sequences from human and non-human primates. Results showed that at the 
      first place three evolutionary steps would have been necessary for the generation 
      of HLA-B*1516 and B*1517 alleles: (1) a non-human primate step with the 
      generation of a major histocompatibility complex (MHC)-B*1516/1517-like allele; 
      (2) a human or non-human primate step with two different ways of evolution 
      generating a MHC-B*1516 and a MHC-B*1517 ancestors; and (3) a human step 
      consisting of the generation of HLA-B*1516 and HLA-B*15170101 alleles. After 
      that, HLA-B*1567, B*1595 B*151701012, and B*151702 alleles would be generated by 
      point mutation events. In conclusion these alleles are generated by two different 
      evolutionary pathways. The generation of these alleles points out the importance 
      of the exons/introns in the generation of the evolution of HLA alleles.
FAU - Roman, Angela
AU  - Roman A
AD  - Unidad de Inmunoterapia Celular, Instituto de Salud Carlos III, Centro Nacional 
      de Microbiologia, Majadahonda, Madrid, Spain.
FAU - Cervera, Isabel
AU  - Cervera I
FAU - Head, Jacqueline
AU  - Head J
FAU - Rodriguez, Miriam
AU  - Rodriguez M
FAU - Martinez-Laso, Jorge
AU  - Martinez-Laso J
LA  - eng
SI  - GENBANK/EF203076
SI  - GENBANK/EF203077
SI  - GENBANK/EF203078
SI  - GENBANK/EF203079
SI  - GENBANK/EF203080
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071126
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Base Sequence
MH  - *Evolution, Molecular
MH  - *Exons
MH  - Genetic Speciation
MH  - HLA-B Antigens/*genetics
MH  - Humans
MH  - *Introns
MH  - Molecular Sequence Data
MH  - Phylogeny
MH  - Polymorphism, Genetic
MH  - Primates/*genetics
MH  - Sequence Alignment
EDAT- 2008/01/15 09:00
MHDA- 2008/03/06 09:00
CRDT- 2008/01/15 09:00
PHST- 2007/08/16 00:00 [received]
PHST- 2007/10/10 00:00 [revised]
PHST- 2007/10/17 00:00 [accepted]
PHST- 2008/01/15 09:00 [pubmed]
PHST- 2008/03/06 09:00 [medline]
PHST- 2008/01/15 09:00 [entrez]
AID - S0198-8859(07)00462-4 [pii]
AID - 10.1016/j.humimm.2007.10.010 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Dec;68(12):1001-8. doi: 10.1016/j.humimm.2007.10.010. Epub 2007 
      Nov 26.