PMID- 18191938
OWN - NLM
STAT- MEDLINE
DCOM- 20080520
LR  - 20210915
IS  - 0890-6238 (Print)
IS  - 0890-6238 (Linking)
VI  - 25
IP  - 2
DP  - 2008 Feb
TI  - Toxicity of artemisinin [Artemisia annua L.] in two different periods of 
      pregnancy in Wistar rats.
PG  - 239-46
LID - 10.1016/j.reprotox.2007.11.003 [doi]
AB  - Artemisinin compounds are important for treating multidrug-resistant malaria; 
      however, the possible resorption and abnormalities observed in animal 
      reproduction studies may contraindicate artemisinin use during the first 
      trimester. To evaluate whether artemisinin interferes with developmental outcomes 
      at different periods of pregnancy, Wistar rats were treated by gavage with 
      increasing doses of 7, 35 and 70 mg/kg/day from gestational day [GD] 7 to 13 or 
      14 to 20. Viable embryos and post-implantation losses, and progestagens and 
      testosterone levels, were monitored in the former treatment group and pregnancy 
      and outcomes data, post-implantation losses and male and female developmental 
      endpoints of the offspring were evaluated in the latter treatment group. Results 
      indicate toxicity for both periods of treatment, with lower sensitivity at later 
      stages of pregnancy. The results showed that dosing with 35 or 75 mg/kg of 
      artemisinin caused high percentages of post-implantation losses that correlated 
      with a trend to lower maternal progestagens and a significant maternal 
      testosterone decrease. These findings demonstrate that oral administration of 
      artemisinin can adversely effect post-implantation development and pregnancy in 
      the rat.
FAU - Boareto, Ana C
AU  - Boareto AC
AD  - Department of Pharmacology, Federal University of Parana, Curitiba, PR, Brazil. 
      boaretoana@gmail.com
FAU - Muller, Juliane C
AU  - Muller JC
FAU - Bufalo, Aedra C
AU  - Bufalo AC
FAU - Botelho, Giuliana G K
AU  - Botelho GG
FAU - de Araujo, Samanta L
AU  - de Araujo SL
FAU - Foglio, Mary Ann
AU  - Foglio MA
FAU - de Morais, Rosana N
AU  - de Morais RN
FAU - Dalsenter, Paulo R
AU  - Dalsenter PR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071117
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Antimalarials)
RN  - 0 (Artemisinins)
RN  - 3XMK78S47O (Testosterone)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 9RMU91N5K2 (artemisinin)
SB  - IM
MH  - Animals
MH  - Antimalarials/*toxicity
MH  - Artemisia annua/*toxicity
MH  - Artemisinins/*toxicity
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetus/*drug effects
MH  - Male
MH  - Pregnancy
MH  - Progesterone/blood
MH  - Rats
MH  - Rats, Wistar
MH  - Testosterone/blood
EDAT- 2008/01/15 09:00
MHDA- 2008/05/21 09:00
CRDT- 2008/01/15 09:00
PHST- 2007/05/28 00:00 [received]
PHST- 2007/10/10 00:00 [revised]
PHST- 2007/11/08 00:00 [accepted]
PHST- 2008/01/15 09:00 [pubmed]
PHST- 2008/05/21 09:00 [medline]
PHST- 2008/01/15 09:00 [entrez]
AID - S0890-6238(07)00297-3 [pii]
AID - 10.1016/j.reprotox.2007.11.003 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2008 Feb;25(2):239-46. doi: 10.1016/j.reprotox.2007.11.003. Epub 
      2007 Nov 17.