PMID- 18194437
OWN - NLM
STAT- MEDLINE
DCOM- 20080606
LR  - 20181113
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 105
IP  - 4
DP  - 2008 May
TI  - Long-term changes in neurotrophic factor expression in distal nerve stump 
      following denervation and reinnervation with motor or sensory nerve.
PG  - 1244-52
LID - 10.1111/j.1471-4159.2008.05224.x [doi]
AB  - Several factors have been proposed to account for poor motor recovery after 
      prolonged denervation, including motor neuron cell death and incomplete or poor 
      regeneration of motor fibers into the muscle. Both may result from failure of the 
      muscle and the distal motor nerve stump to continue expression of neurotrophic 
      factors following delayed muscle reinnervation. This study investigated whether 
      regenerating motor or sensory axons modulate distal nerve neurotrophic factor 
      expression. We found that transected distal tibial nerve up-regulated 
      brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic 
      factor (GDNF) mRNA, down-regulated neurotrophin-3 and ciliary neurotrophic factor 
      mRNA, and that although these levels returned to normal with regeneration, the 
      chronically denervated distal nerve stump continued to express these neurotrophic 
      factors for at least 6 months following injury. A sensory nerve (the cutaneous 
      saphenous nerve) sutured to distal tibial nerve lowered injury-induced BDNF and 
      GDNF mRNA levels in distal stump, but repair with a mixed nerve (peroneal, 
      containing muscle and cutaneous axons) was more effective. Repair with sensory or 
      mixed nerves did not affect nerve growth factor or neurotrophin-3 expression. 
      Thus, distal nerve contributed to a neurotrophic environment for nerve 
      regeneration for at least 6 months, and sensory nerve repair helped normalize 
      distal nerve neurotrophic factor mRNA expression following denervation. 
      Furthermore, as BDNF and GDNF levels in distal stump increased following 
      denervation and returned to control levels following reinnervation, their levels 
      serve as markers for the status of regeneration by either motor or sensory nerve.
FAU - Michalski, B
AU  - Michalski B
AD  - Department of Psychiatry and Behavioural Neurosciences, McMaster University, 
      Hamilton, Ontario, Canada.
FAU - Bain, J R
AU  - Bain JR
FAU - Fahnestock, M
AU  - Fahnestock M
LA  - eng
GR  - 64270/Canadian Institutes of Health Research/Canada
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080110
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Animals
MH  - Gene Expression Regulation/physiology
MH  - Male
MH  - Motor Neurons/*physiology
MH  - Muscle Denervation/methods
MH  - Muscle, Skeletal/*innervation/physiology
MH  - Nerve Growth Factors/*biosynthesis/genetics
MH  - Nerve Regeneration/*physiology
MH  - Neurons, Afferent/*physiology
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Tibial Nerve/*injuries/physiology
MH  - Time
PMC - PMC3414532
MID - CAMS2286
OID - NLM: CAMS2286
EDAT- 2008/01/16 09:00
MHDA- 2008/06/07 09:00
PMCR- 2012/08/08
CRDT- 2008/01/16 09:00
PHST- 2008/01/16 09:00 [pubmed]
PHST- 2008/06/07 09:00 [medline]
PHST- 2008/01/16 09:00 [entrez]
PHST- 2012/08/08 00:00 [pmc-release]
AID - JNC5224 [pii]
AID - 10.1111/j.1471-4159.2008.05224.x [doi]
PST - ppublish
SO  - J Neurochem. 2008 May;105(4):1244-52. doi: 10.1111/j.1471-4159.2008.05224.x. Epub 
      2008 Jan 10.