PMID- 18194575
OWN - NLM
STAT- MEDLINE
DCOM- 20080326
LR  - 20181113
IS  - 1475-925X (Electronic)
IS  - 1475-925X (Linking)
VI  - 7
DP  - 2008 Jan 14
TI  - Simulation and analysis of spatio-temporal maps of gastrointestinal motility.
PG  - 2
LID - 10.1186/1475-925X-7-2 [doi]
AB  - BACKGROUND: Spatio-temporal (ST) maps provide a method for visualizing a 
      temporally evolving and spatially varying field, which can also be used in the 
      analysis of gastrointestinal motility. However, it is not always clear what the 
      underlying contractions are that are represented in ST maps and whether some 
      types of contractions are poorly represented or possibly not at all. METHODS: To 
      analyze the translation from stationary or propagating rhythmic contractions of 
      the intestine to ST maps, a simulation program was used to represent different 
      patterns of intestinal contraction and to construct their corresponding ST maps. 
      A number of different types of contractions were simulated and their ST maps 
      analyzed. RESULTS: Circular strong contractions were well represented in ST maps 
      as well as their frequency and velocity. Longitudinal contractions were not 
      detected at all. Combinations of circular and longitudinal contractions were, to 
      a limited extent detectable at a point in space and time. The method also enabled 
      the construction of specific ST-patterns to mimic real-life ST maps and the 
      analysis of the corresponding contraction patterns. CONCLUSION: Spatio-temporal 
      simulations provide a method to understand, teach and analyze ST maps. This 
      approach could be useful to determine characteristics of contractions under a 
      variety of circumstances.
FAU - Lammers, Wim J E P
AU  - Lammers WJ
AD  - Department of Physiology, Faculty of Medicine and Health Sciences, UAE 
      University, Al Ain, United Arab Emirates. wlammers@smoothmap.org
FAU - Cheng, Leo K
AU  - Cheng LK
LA  - eng
GR  - R01 DK064775/DK/NIDDK NIH HHS/United States
GR  - R01 DK64775/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20080114
PL  - England
TA  - Biomed Eng Online
JT  - Biomedical engineering online
JID - 101147518
SB  - IM
MH  - Animals
MH  - Biological Clocks/*physiology
MH  - Computer Simulation
MH  - Gastrointestinal Motility/*physiology
MH  - Humans
MH  - Intestine, Small/*physiology
MH  - *Models, Biological
MH  - Muscle Contraction/*physiology
MH  - Muscle, Smooth/*physiology
MH  - Oscillometry/methods
PMC - PMC2254420
EDAT- 2008/01/16 09:00
MHDA- 2008/03/28 09:00
PMCR- 2008/01/14
CRDT- 2008/01/16 09:00
PHST- 2007/10/03 00:00 [received]
PHST- 2008/01/14 00:00 [accepted]
PHST- 2008/01/16 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2008/01/16 09:00 [entrez]
PHST- 2008/01/14 00:00 [pmc-release]
AID - 1475-925X-7-2 [pii]
AID - 10.1186/1475-925X-7-2 [doi]
PST - epublish
SO  - Biomed Eng Online. 2008 Jan 14;7:2. doi: 10.1186/1475-925X-7-2.