PMID- 18196520
OWN - NLM
STAT- MEDLINE
DCOM- 20080505
LR  - 20080207
IS  - 1615-9306 (Print)
IS  - 1615-9306 (Linking)
VI  - 31
IP  - 2
DP  - 2008 Feb
TI  - Analysis of volatile components of drugs and explosives by solid phase 
      microextraction-ion mobility spectrometry.
PG  - 402-12
LID - 10.1002/jssc.200700292 [doi]
AB  - Current ion mobility spectrometry (IMS) devices are used to detect drugs and 
      explosives in the form of particles and, in cases where the vapor pressure of the 
      drugs or explosives is sufficiently high, the gas can be sampled and detected 
      directly. The aim of this study is to demonstrate the use of solid phase 
      microextraction (SPME) as a preconcentration technique coupled to an IMS for the 
      detection of odor signature compounds of drugs and explosives. The reduced 
      mobilities (K(o)) and IMS operating conditions for the odor signature compounds 
      of cocaine, marijuana, and 3,4-methylenedioxy-N-methylamphetamine (MDMA) are 
      reported for the first time. LODs, linear dynamic ranges (LDRs), and the 
      precision of the analysis of these odor signature compounds, and the explosive 
      taggant 2,3-dimethyl-2,3-dinitrobutane (DMNB) were obtained by SPME-IMS and 
      normal IMS conditions. The systematic optimization of the IMS operating 
      parameters for the detection of these odor compounds is also reported 
      incorporating the use of genetic algorithms (GAs) for finding the optimal 
      settings for the detection of these compounds of interest. These results support 
      the case for targeting volatile components as a presumptive detection for the 
      presence of the parent compounds of drugs and explosives. Furthermore, the 
      IMS-specific GA developed can be used as an optimization tool for the detection 
      of other compounds of interest in future work.
FAU - Lai, Hanh
AU  - Lai H
AD  - Department of Chemistry and Biochemistry, International Forensic Research 
      Institute, Florida International University, FL 33199, USA.
FAU - Guerra, Patricia
AU  - Guerra P
FAU - Joshi, Monica
AU  - Joshi M
FAU - Almirall, Jose R
AU  - Almirall JR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - Germany
TA  - J Sep Sci
JT  - Journal of separation science
JID - 101088554
RN  - 0 (Explosive Agents)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Explosive Agents/*analysis
MH  - Pharmaceutical Preparations/*analysis
MH  - Sensitivity and Specificity
MH  - Spectrum Analysis/*methods
MH  - Volatilization
EDAT- 2008/01/16 09:00
MHDA- 2008/05/06 09:00
CRDT- 2008/01/16 09:00
PHST- 2008/01/16 09:00 [pubmed]
PHST- 2008/05/06 09:00 [medline]
PHST- 2008/01/16 09:00 [entrez]
AID - 10.1002/jssc.200700292 [doi]
PST - ppublish
SO  - J Sep Sci. 2008 Feb;31(2):402-12. doi: 10.1002/jssc.200700292.