PMID- 18199818
OWN - NLM
STAT- MEDLINE
DCOM- 20080612
LR  - 20161025
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 99
IP  - 3
DP  - 2008 Mar
TI  - Behavioral and physiological characterization of sensorimotor gating in the 
      goldfish startle response.
PG  - 1493-502
LID - 10.1152/jn.00959.2007 [doi]
AB  - Prepulse inhibition (PPI) is typically associated with an attenuation of auditory 
      startle behavior in mammals and is presumably mediated within the brainstem 
      startle circuit. However, the inhibitory mechanisms underlying PPI are not yet 
      clear. We addressed this question with complementary behavioral and in vivo 
      electrophysiological experiments in the startle escape circuit of goldfish, the 
      Mauthner cell (M-cell) system. In the behavioral experiments we observed a 77.5% 
      attenuation (PPI) of startle escape probability following auditory prepulse-pulse 
      stimulation. The PPI effect was observed for prepulse-pulse interstimulus 
      intervals (ISIs) ranging from 20 to 600 ms and its magnitude depended linearly on 
      prepulse intensity over a range of 14 dB. Electrophysiological recordings of 
      synaptic responses to a sound pulse in the M-cell, which is the sensorimotor 
      neuron initiating startle escapes, showed a 21% reduction in amplitude of the 
      dendritic postsynaptic potential (PSP) and a 23% reduction of the somatic PSP 
      following a prepulse. In addition, a prepulse evoked a long-lasting (500 ms) 
      decrease in M-cell excitability indicated by 1) an increased threshold current, 
      2) an inhibitory shunt of the action potential (AP), and 3) by a linearized 
      M-cell membrane, which effectively impedes M-cell AP generation. Comparing the 
      magnitude and kinetics of inhibitory shunts evoked by a prepulse in the M-cell 
      dendrite and soma revealed a disproportionately larger and longer-lasting 
      inhibition in the dendrite. These results suggest that the observed PPI-type 
      attenuation of startle behavior can be correlated to distinct postsynaptic 
      mechanisms mediated primarily at the M-cell lateral dendrite.
FAU - Neumeister, Heike
AU  - Neumeister H
AD  - Dominick Purpura Department of Neuroscience, Albert Einstein College of Medicine, 
      1300 Morris Park Ave., Bronx, NY 10461, USA.
FAU - Szabo, Theresa M
AU  - Szabo TM
FAU - Preuss, Thomas
AU  - Preuss T
LA  - eng
GR  - R01 NS015335/NS/NINDS NIH HHS/United States
GR  - T32 NS007439/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20080116
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Acoustic Stimulation/methods
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal
MH  - Dose-Response Relationship, Immunologic
MH  - Electric Stimulation
MH  - Escape Reaction/*physiology
MH  - Evoked Potentials, Auditory/*physiology
MH  - Goldfish/*physiology
MH  - Neural Inhibition/*physiology
MH  - Probability
MH  - Reaction Time/physiology
MH  - Reflex, Startle/*physiology
MH  - Sensory Thresholds/*physiology/radiation effects
EDAT- 2008/01/18 09:00
MHDA- 2008/06/13 09:00
CRDT- 2008/01/18 09:00
PHST- 2008/01/18 09:00 [pubmed]
PHST- 2008/06/13 09:00 [medline]
PHST- 2008/01/18 09:00 [entrez]
AID - 00959.2007 [pii]
AID - 10.1152/jn.00959.2007 [doi]
PST - ppublish
SO  - J Neurophysiol. 2008 Mar;99(3):1493-502. doi: 10.1152/jn.00959.2007. Epub 2008 
      Jan 16.