PMID- 18200572
OWN - NLM
STAT- MEDLINE
DCOM- 20080313
LR  - 20191210
IS  - 1542-9741 (Electronic)
IS  - 1542-9733 (Linking)
VI  - 83
IP  - 1
DP  - 2008 Feb
TI  - Evaluation of embryo-fetal development in rats housed in concrete or hwangto 
      cages during pregnancy.
PG  - 32-9
LID - 10.1002/bdrb.20141 [doi]
AB  - BACKGROUND: Recently, it was reported that the 4-week exposure of rats to a 
      concrete building environment under cool temperatures (11.7-12.1 degrees C) had 
      adverse effects on the general health parameters. This study examined the 
      potential effects of concrete and hwangto building environments on pregnant dams 
      and embryo-fetal development in Sprague-Dawley rats. METHODS: Groups of 10 mated 
      females were exposed to polycarbonate (control), concrete, or hwangto cages from 
      gestational days (GD) 0 to 20 under cool temperatures (11.9-12.5 degrees C). All 
      the females underwent a caesarean section on GD 20, and their fetuses were 
      examined for any morphological abnormalities. RESULTS: The temperatures in the 
      cages were similar in all groups but the relative humidity in the concrete and 
      hwangto groups were higher than in the control group. The concentration of 
      volatile organic compounds in the hwangto group during the study period was lower 
      than in the control group. In the concrete group, maternal effects manifested as 
      an increase in the incidence of clinical signs, a lower body weight, and a 
      decrease in the thymus and ovary weights. Developmental effects included 
      increased post-implantation loss and decreased litter size. In contrast, in the 
      hwangto group, there were no exposure-related adverse effects on the maternal and 
      developmental parameters. CONCLUSIONS: Overall, the exposure of pregnant rats to 
      a concrete building environment under cool temperatures has adverse effects on 
      the clinical signs, body weight, organ weight, and embryo-fetal development. On 
      the other hand, exposure to a hwangto building environment does not have any 
      adverse effects on pregnant dams or on embryo-fetal development in rats.
CI  - (c) 2008 Wiley-Liss, Inc.
FAU - Lee, J C
AU  - Lee JC
AD  - College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of 
      Korea.
FAU - Ahn, T H
AU  - Ahn TH
FAU - Yang, Y S
AU  - Yang YS
FAU - Moon, C J
AU  - Moon CJ
FAU - Kim, S H
AU  - Kim SH
FAU - Kim, Y B
AU  - Kim YB
FAU - Park, S C
AU  - Park SC
FAU - Kim, J C
AU  - Kim JC
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Birth Defects Res B Dev Reprod Toxicol
JT  - Birth defects research. Part B, Developmental and reproductive toxicology
JID - 101155115
RN  - 0 (Air Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Air Pollutants/analysis
MH  - *Animal Husbandry
MH  - Animals
MH  - Construction Materials/*toxicity
MH  - Embryonic Development/*physiology
MH  - Female
MH  - Fetal Development/*physiology
MH  - *Housing, Animal
MH  - Humidity
MH  - Male
MH  - Maternal Exposure
MH  - Organic Chemicals/analysis
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Specific Pathogen-Free Organisms
EDAT- 2008/01/18 09:00
MHDA- 2008/03/14 09:00
CRDT- 2008/01/18 09:00
PHST- 2008/01/18 09:00 [pubmed]
PHST- 2008/03/14 09:00 [medline]
PHST- 2008/01/18 09:00 [entrez]
AID - 10.1002/bdrb.20141 [doi]
PST - ppublish
SO  - Birth Defects Res B Dev Reprod Toxicol. 2008 Feb;83(1):32-9. doi: 
      10.1002/bdrb.20141.