PMID- 18201830
OWN - NLM
STAT- MEDLINE
DCOM- 20080612
LR  - 20191219
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 151
IP  - 4
DP  - 2008 Feb 19
TI  - Activin induces long-lasting N-methyl-D-aspartate receptor activation via 
      scaffolding PDZ protein activin receptor interacting protein 1.
PG  - 1225-35
LID - 10.1016/j.neuroscience.2007.12.012 [doi]
AB  - Calcium entry into the postsynaptic neuron through N-methyl-D-aspartate-type 
      glutamate receptors (NMDARs) triggers the induction of long-term potentiation 
      (LTP), which is considered to contribute to synaptic plasticity and plays a 
      critical role in behavioral learning. We report here that activin, a member of 
      the transforming growth factor-beta (TGF-beta) superfamily, promotes 
      phosphorylation of NMDARs and increases the Ca2+ influx through these receptors 
      in primary cultured rat hippocampal neurons. This signal transduction occurs in a 
      functional complex of activin receptors, NMDARs, and Src family tyrosine kinases, 
      including Fyn, formed on a multimer of postsynaptic scaffolding postsynaptic 
      density protein 95/Dlg/ZO-1 (PDZ), activin receptor interacting protein 1 
      (ARIP1). Activin-induced NMDAR activation persists for more than 24 h, which is 
      complimentary to the activation time of NMDARs by brain-derived neurotrophic 
      factor (BDNF). Our results suggest that activin is a unique and powerful 
      potentiator for NMDAR-dependent signaling, which could be involved in the 
      regulatory mechanisms of synaptic plasticity.
FAU - Kurisaki, A
AU  - Kurisaki A
AD  - Institute for Enzyme Research, The University of Tokushima, Kuramoto, Tokushima 
      770-8503, Japan. akikuri@hotmail.com
FAU - Inoue, I
AU  - Inoue I
FAU - Kurisaki, K
AU  - Kurisaki K
FAU - Yamakawa, N
AU  - Yamakawa N
FAU - Tsuchida, K
AU  - Tsuchida K
FAU - Sugino, H
AU  - Sugino H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071215
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Benzamides)
RN  - 0 (Dioxoles)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Proteins)
RN  - 0 (Quinoxalines)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 104625-48-1 (Activins)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 62T278S1MX (FG 9041)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - EC 2.7.4.8 (Guanylate Kinases)
RN  - EC 2.7.4.8 (Magi2 protein, mouse)
RN  - EC 4.2.1.11 (Phosphopyruvate Hydratase)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Activins/*pharmacology
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Benzamides/pharmacology
MH  - Calcium/metabolism
MH  - Cells, Cultured
MH  - Dioxoles/pharmacology
MH  - Dizocilpine Maleate/pharmacology
MH  - Embryo, Mammalian
MH  - Enzyme Inhibitors/pharmacology
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Glutamic Acid/pharmacology
MH  - Guanylate Kinases
MH  - Hippocampus/cytology
MH  - Immunoprecipitation
MH  - Neurons/*drug effects
MH  - Phosphopyruvate Hydratase/metabolism
MH  - Proteins/*physiology
MH  - Quinoxalines/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Time Factors
MH  - Transfection
EDAT- 2008/01/19 09:00
MHDA- 2008/06/13 09:00
CRDT- 2008/01/19 09:00
PHST- 2007/05/18 00:00 [received]
PHST- 2007/11/23 00:00 [revised]
PHST- 2007/12/15 00:00 [accepted]
PHST- 2008/01/19 09:00 [pubmed]
PHST- 2008/06/13 09:00 [medline]
PHST- 2008/01/19 09:00 [entrez]
AID - S0306-4522(07)01566-7 [pii]
AID - 10.1016/j.neuroscience.2007.12.012 [doi]
PST - ppublish
SO  - Neuroscience. 2008 Feb 19;151(4):1225-35. doi: 
      10.1016/j.neuroscience.2007.12.012. Epub 2007 Dec 15.