PMID- 18201899
OWN - NLM
STAT- MEDLINE
DCOM- 20080804
LR  - 20080404
IS  - 1095-9327 (Electronic)
IS  - 1044-7431 (Linking)
VI  - 37
IP  - 4
DP  - 2008 Apr
TI  - Conditional genetic labeling of mitral cells of the mouse accessory olfactory 
      bulb to visualize the organization of their apical dendritic tufts.
PG  - 708-18
LID - 10.1016/j.mcn.2007.12.016 [doi]
AB  - Chemical information captured through the vomeronasal sensory neurons is 
      transmitted to mitral cells in the accessory olfactory bulb (AOB). Morphological 
      characterization of AOB mitral cells is crucial to reveal the mechanisms 
      underlying pheromone and other chemical information processing. Here, we 
      developed a conditional genetic approach to visualize single AOB mitral cells in 
      mice and analyzed the distribution of their apical dendritic tufts and cell 
      bodies. We found that there is a subpopulation of superficial AOB mitral cells 
      with small cell bodies and simple dendritic arborization. We also showed that 
      segregation of the anterior and posterior AOB appears incomplete at the level of 
      the mitral cell positions. Furthermore, we demonstrated that significant 
      population of the anterior AOB mitral cells has multiple apical dendritic tufts 
      organized in a quite small range along the dorsal-ventral axis. These findings 
      have important implications in how various chemical signals may be processed in 
      the AOB.
FAU - Yonekura, Junichiro
AU  - Yonekura J
AD  - Molecular Neurogenetics Unit, HMRO, Kyoto University Graduate School of Medicine, 
      Yoshida-Konoe, Sakyo, Kyoto 606-8501, Japan.
FAU - Yokoi, Mineto
AU  - Yokoi M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20071215
PL  - United States
TA  - Mol Cell Neurosci
JT  - Molecular and cellular neurosciences
JID - 9100095
SB  - IM
MH  - Animals
MH  - Brain Mapping/methods
MH  - Dendrites/chemistry/*genetics/*ultrastructure
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Olfactory Bulb/chemistry/*cytology/*physiology
EDAT- 2008/01/19 09:00
MHDA- 2008/08/05 09:00
CRDT- 2008/01/19 09:00
PHST- 2007/10/10 00:00 [received]
PHST- 2007/11/26 00:00 [revised]
PHST- 2007/12/07 00:00 [accepted]
PHST- 2008/01/19 09:00 [pubmed]
PHST- 2008/08/05 09:00 [medline]
PHST- 2008/01/19 09:00 [entrez]
AID - S1044-7431(07)00292-8 [pii]
AID - 10.1016/j.mcn.2007.12.016 [doi]
PST - ppublish
SO  - Mol Cell Neurosci. 2008 Apr;37(4):708-18. doi: 10.1016/j.mcn.2007.12.016. Epub 
      2007 Dec 15.