PMID- 18202573
OWN - NLM
STAT- MEDLINE
DCOM- 20080415
LR  - 20080122
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 40
IP  - 2
DP  - 2008 Feb
TI  - Heart rate recovery predicts mortality and cardiovascular events in patients with 
      type 2 diabetes.
PG  - 288-95
LID - 10.1249/mss.0b013e31815c4844 [doi]
AB  - PURPOSE: Heart rate recovery (HRR) immediately after peak exercise has utility as 
      a predictor of all-cause mortality. However, a prognostic role for HRR has not 
      been specifically evaluated in patients with type 2 diabetes mellitus (T2DM), nor 
      has an association between HRR and cardiovascular (CV) events been documented. 
      This study investigated whether HRR is predictive of all-cause mortality, CV 
      mortality, and CV events in asymptomatic patients with T2DM. METHODS: HRR in 
      subjects with T2DM was obtained via chart review of peak exercise treadmill tests 
      (N = 890) performed at entry into the Appropriate Blood Pressure Control in 
      Diabetes trial. Survival analysis was used to test the association of 1- and 
      2-min HRR with all-cause mortality, CV mortality, and CV events during the 
      follow-up period. RESULTS: Subjects were followed for a median of 5.0 yr. 
      All-cause mortality and CV events were significantly greater among the lowest 
      quintile (< 12 bpm) of 1-min HRR compared with the fourth (23-28 bpm) quintile. 
      Similarly all-cause mortality and CV events were significantly greater among the 
      lowest quintile (< 28 bpm) of 2-min HRR compared with the third quintile (37-42 
      bpm) quintile. After adjustment for traditional cardiac risk factors, attenuated 
      1- and 2-min HRR remained significantly associated with increased risk of CV 
      events as compared with those without attenuation. CONCLUSIONS: HRR provides 
      information beyond traditional CV risk factors that could aid in the clinical 
      risk stratification of patients with T2DM. The results suggest that HRR results 
      should be incorporated into standard diagnostic treadmill testing reports and 
      target those patients with T2DM and attenuated HRR who can benefit from directed 
      therapies.
FAU - Chacko, Karen M
AU  - Chacko KM
AD  - University of Colorado at Denver and Health Sciences Center, Colorado Prevention 
      Center, 789 Sherman Street, Denver, CO 80203, USA.
FAU - Bauer, Timothy A
AU  - Bauer TA
FAU - Dale, Rita A
AU  - Dale RA
FAU - Dixon, James A
AU  - Dixon JA
FAU - Schrier, Robert W
AU  - Schrier RW
FAU - Estacio, Raymond O
AU  - Estacio RO
LA  - eng
GR  - DK 50298-02/DK/NIDDK NIH HHS/United States
GR  - F32 DK 078413-01/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
SB  - IM
MH  - Aged
MH  - Cardiac Output, Low/*etiology/mortality
MH  - Colorado
MH  - Diabetes Mellitus, Type 2/*mortality/physiopathology
MH  - Exercise/*physiology
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
EDAT- 2008/01/19 09:00
MHDA- 2008/04/16 09:00
CRDT- 2008/01/19 09:00
PHST- 2008/01/19 09:00 [pubmed]
PHST- 2008/04/16 09:00 [medline]
PHST- 2008/01/19 09:00 [entrez]
AID - 10.1249/mss.0b013e31815c4844 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2008 Feb;40(2):288-95. doi: 10.1249/mss.0b013e31815c4844.