PMID- 18203954
OWN - NLM
STAT- MEDLINE
DCOM- 20080515
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 111
IP  - 7
DP  - 2008 Apr 1
TI  - Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature 
      dendritic cells through dissolution of their podosomes.
PG  - 3579-90
LID - 10.1182/blood-2007-08-107755 [doi]
AB  - Dendritic cells (DCs) control T cell-based immunity. To do so they need to mature 
      and migrate to sites of T-cell priming. We have previously shown that cognate 
      interactions of human CD4+ T cells with DCs induce DC maturation. We show here 
      that CC chemokines produced during antigen-specific T-DC interactions also induce 
      strong morphologic modifications and migration of immature DCs. These 
      modifications are required for efficient T-cell activation. Moreover, we show 
      that CC chemokines produced during antigen-specific DC-T-cell interactions induce 
      the dissolution of structures involved in cell motility and present on immature 
      DCs (ie, podosomes). We thus propose a model in which chemokines secreted during 
      Ag-specific contact between T cells and DCs induce disassembly of interacting and 
      neighboring immature DC podosomes, leading to recruitment of more immature DCs 
      toward sites of antigenic stimulation and to amplification of T-cell responses.
FAU - Nobile, Cinzia
AU  - Nobile C
AD  - Institut Curie, Centre de Recherce, Paris, France.
FAU - Lind, Marianne
AU  - Lind M
FAU - Miro, Francesc
AU  - Miro F
FAU - Chemin, Karine
AU  - Chemin K
FAU - Tourret, Marie
AU  - Tourret M
FAU - Occhipinti, Giovanni
AU  - Occhipinti G
FAU - Dogniaux, Stephanie
AU  - Dogniaux S
FAU - Amigorena, Sebastian
AU  - Amigorena S
FAU - Hivroz, Claire
AU  - Hivroz C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080118
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Chemokines)
SB  - IM
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cell Communication/*immunology
MH  - Cell Movement/*immunology
MH  - Cells, Cultured
MH  - Chemokines/immunology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Lymphocyte Activation/*immunology
MH  - *Models, Immunological
EDAT- 2008/01/22 09:00
MHDA- 2008/05/16 09:00
CRDT- 2008/01/22 09:00
PHST- 2008/01/22 09:00 [pubmed]
PHST- 2008/05/16 09:00 [medline]
PHST- 2008/01/22 09:00 [entrez]
AID - S0006-4971(20)43081-2 [pii]
AID - 10.1182/blood-2007-08-107755 [doi]
PST - ppublish
SO  - Blood. 2008 Apr 1;111(7):3579-90. doi: 10.1182/blood-2007-08-107755. Epub 2008 
      Jan 18.