PMID- 18204839 OWN - NLM STAT- MEDLINE DCOM- 20090827 LR - 20211020 IS - 1432-5195 (Electronic) IS - 0341-2695 (Print) IS - 0341-2695 (Linking) VI - 33 IP - 3 DP - 2009 Jun TI - Study of rotating permanent magnetic field to treat steroid-induced osteonecrosis of femoral head. PG - 617-23 LID - 10.1007/s00264-007-0506-7 [doi] AB - Sixty New Zealand rabbit models with steroid-induced necrosis of femoral head were exposed to a rotating permanent magnetic field (RPMF) (group A1-2 h/d for one month and group A2-2 h/d for two months), and the changes of femoral head, blood viscosity, serum cholesterol, triglyceride, and pressure within the hip joint cavity were measured and statistically analysed compared to that of control group (B1 and B2) and sham group (C1 and C2). After RPMF treatment, the osteogenesis regeneration of the necrotic femoral head was markedly improved, as was shown by micro-CT. Blood viscosity, serum cholesterol, triglyceride, and pressure in the hip joint cavity were found significantly reduced. RPMF could affect various critical aspects in the course of femoral head necrosis, which will be a promising measure in the prevention and treatment of steroid-induced necrosis of femoral head, especially in the early stage. FAU - Pan, Xiaohua AU - Pan X AD - Department of Orthopedics, The Second Clinical Medical College, Jinan University, Shenzhen People's Hospital, Guangdong Province, China. FAU - Xiao, Deming AU - Xiao D FAU - Zhang, Xiaoyun AU - Zhang X FAU - Huang, YuanShuai AU - Huang Y FAU - Lin, Bowen AU - Lin B LA - eng PT - Journal Article DEP - 20080118 PL - Germany TA - Int Orthop JT - International orthopaedics JID - 7705431 RN - 0 (Glucocorticoids) RN - 0 (Triglycerides) RN - 97C5T2UQ7J (Cholesterol) RN - 9PHQ9Y1OLM (Prednisolone) SB - IM MH - Animals MH - Blood Viscosity MH - Bone Regeneration/physiology MH - Cholesterol/blood MH - Disease Models, Animal MH - Femur Head/diagnostic imaging/*drug effects/pathology MH - Femur Head Necrosis/chemically induced/pathology/*therapy MH - Glucocorticoids/*adverse effects MH - Hip Joint/diagnostic imaging/pathology/physiopathology MH - Magnetic Field Therapy/*methods MH - Male MH - Prednisolone/*adverse effects MH - Pressure MH - Rabbits MH - Tomography, X-Ray Computed MH - Treatment Outcome MH - Triglycerides/blood PMC - PMC2903078 EDAT- 2008/01/22 09:00 MHDA- 2009/08/28 09:00 PMCR- 2010/06/01 CRDT- 2008/01/22 09:00 PHST- 2007/11/01 00:00 [received] PHST- 2007/11/26 00:00 [accepted] PHST- 2007/11/25 00:00 [revised] PHST- 2008/01/22 09:00 [pubmed] PHST- 2009/08/28 09:00 [medline] PHST- 2008/01/22 09:00 [entrez] PHST- 2010/06/01 00:00 [pmc-release] AID - 506 [pii] AID - 10.1007/s00264-007-0506-7 [doi] PST - ppublish SO - Int Orthop. 2009 Jun;33(3):617-23. doi: 10.1007/s00264-007-0506-7. Epub 2008 Jan 18.