PMID- 18205169 OWN - NLM STAT- MEDLINE DCOM- 20081204 LR - 20211020 IS - 1552-485X (Electronic) IS - 1552-4841 (Linking) VI - 147B IP - 6 DP - 2008 Sep 5 TI - Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. PG - 814-21 LID - 10.1002/ajmg.b.30686 [doi] AB - Depression is common and a major cause of morbidity and mortality and is also known to have serious effects on quality of life. Both clinical and pharmacologic studies have implicated the role of brain-derived neurotrophic factor (BDNF) as a susceptibility locus for the development of mental illness, including depression, bipolar disorder, and schizophrenia. Population-based genetic studies have examined the association between BDNF and a variety of depression outcomes, but the results have not clearly established the role of BDNF in the development of this complex disorder. The aim of this study was to test for associations between two genetic variants in BDNF, Val66Met (rs6265) and -270 C > T, and depression measured in two independent samples. In this analysis we included 3,548 participants from British Women's Heart and Health Study (BWHHS) and 6,836 mothers from Avon Longitudinal Study of Parents and Children (ALSPAC) who had complete data on genotype and depression outcomes. We did not detect any strong evidence of associations between any of the two polymorphisms and indicators of depression in either BWHHS or ALSPAC samples. Further, we carried out a systematic review and meta-analysis of all association studies of these two BDNF polymorphisms and depression. The meta-analysis of Val66Met in depression obtained an overall summary OR of 1.06 (95% CI: 0.89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. Our findings suggest that BDNF genotype does not exert a major influence on the development of depression. CI - 2008 Wiley-Liss, Inc. FAU - Chen, Lina AU - Chen L AD - Department of Social Medicine, University of Bristol, Bristol, United Kingdom. FAU - Lawlor, Debbie A AU - Lawlor DA FAU - Lewis, Sarah J AU - Lewis SJ FAU - Yuan, Wei AU - Yuan W FAU - Abdollahi, Mohammad R AU - Abdollahi MR FAU - Timpson, Nicholas J AU - Timpson NJ FAU - Day, Ian N M AU - Day IN FAU - Ebrahim, Shah AU - Ebrahim S FAU - Smith, George Davey AU - Smith GD FAU - Shugart, Yin Y AU - Shugart YY LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - G0600705/MRC_/Medical Research Council/United Kingdom GR - BHF_/British Heart Foundation/United Kingdom GR - DH_/Department of Health/United Kingdom GR - G9815508/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Med Genet B Neuropsychiatr Genet JT - American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics JID - 101235742 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - Aged MH - Algorithms MH - Brain-Derived Neurotrophic Factor/*genetics MH - Cohort Studies MH - Depression/epidemiology/*genetics MH - Female MH - *Genetic Linkage MH - Genetic Predisposition to Disease MH - Genotype MH - Humans MH - Male MH - Meta-Analysis as Topic MH - Middle Aged MH - Polymorphism, Single Nucleotide/physiology MH - Pregnancy EDAT- 2008/01/22 09:00 MHDA- 2008/12/17 09:00 CRDT- 2008/01/22 09:00 PHST- 2008/01/22 09:00 [pubmed] PHST- 2008/12/17 09:00 [medline] PHST- 2008/01/22 09:00 [entrez] AID - 10.1002/ajmg.b.30686 [doi] PST - ppublish SO - Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):814-21. doi: 10.1002/ajmg.b.30686.