PMID- 18205762
OWN - NLM
STAT- MEDLINE
DCOM- 20080605
LR  - 20161124
IS  - 1365-2796 (Electronic)
IS  - 0954-6820 (Linking)
VI  - 263
IP  - 6
DP  - 2008 Jun
TI  - Severity of periodontal disease correlates to inflammatory systemic status and 
      independently predicts the presence and angiographic extent of stable coronary 
      artery disease.
PG  - 644-52
LID - 10.1111/j.1365-2796.2007.01916.x [doi]
AB  - BACKGROUND: Periodontal disease (PD) has been recognized as a risk factor for 
      systemic diseases, but its involvement in the pathogenesis of coronary artery 
      disease (CAD) remains debated. OBJECTIVES: We sought to evaluate the potential 
      relations between severity of the PD, inflammatory response and angiographic 
      lesions extent in patients with stable CAD. DESIGN: A total of 131 subjects 
      referred to our centre for coronary angiography were evaluated for presence and 
      extension of CAD, then divided into two groups, one with presence of lesions 
      (cases, n = 85) and other one with absence of lesions (controls, n = 46). Mean 
      periodontal pocket depth (PPkD), high sensitivity C reactive protein (hs-CRP), 
      serum amyloid A protein (SAA) and fibrinogen levels were measured in all 
      patients. RESULTS: Cases and controls did not differ according to their baseline 
      characteristics and prevalence of traditional cardiovascular risk factors. PPkD 
      was greater in patients with CAD than in controls (2.24 +/- 1.28 mm vs 1.50 +/- 
      0.93 mm, P < 0.001 by Student's t-test). Systemic inflammatory response was more 
      pronounced in cases than in controls, with higher values of hs-CRP, SAA and 
      fibrinogen. Furthermore, PPkD values correlated with hs-CRP (r = 0.80, P < 
      0.001), SAA (r = 0.71, P < 0.001), fibrinogen levels (r = 0.72, P < 0.001) and 
      the American College of Cardiology/American Heart Association angiographic score 
      (r = 0.68, P < 0.001) in cases. Multivariate analysis indicated a persistent 
      independent correlation between PPkD and angiographic score after adjustment for 
      inflammatory markers levels. CONCLUSION: In the present study, PD lesions 
      predicted presence of CAD stenosis in patients with cardiovascular risk factors. 
      PD severity was correlated to angiographic extent of coronary lesions, 
      independent of systemic inflammatory status. Those results suggest that these 
      patients might benefit from an intensive periodontal therapy to prevent CAD 
      progression.
FAU - Amabile, N
AU  - Amabile N
AD  - Department of Cardiology, University of Marseille, Hopital Nord, Marseille, 
      France. nicolas.amabile@mail.ap-hm.fr
FAU - Susini, G
AU  - Susini G
FAU - Pettenati-Soubayroux, I
AU  - Pettenati-Soubayroux I
FAU - Bonello, L
AU  - Bonello L
FAU - Gil, J-M
AU  - Gil JM
FAU - Arques, S
AU  - Arques S
FAU - Bonfil, J J
AU  - Bonfil JJ
FAU - Paganelli, F
AU  - Paganelli F
LA  - eng
PT  - Journal Article
DEP - 20080116
PL  - England
TA  - J Intern Med
JT  - Journal of internal medicine
JID - 8904841
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Coronary Angiography
MH  - Coronary Artery Disease/diagnostic imaging/*etiology
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/blood
MH  - Male
MH  - Middle Aged
MH  - Periodontal Pocket/pathology
MH  - Periodontitis/blood/*complications/pathology
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Smoking/adverse effects
EDAT- 2008/01/22 09:00
MHDA- 2008/06/06 09:00
CRDT- 2008/01/22 09:00
PHST- 2008/01/22 09:00 [pubmed]
PHST- 2008/06/06 09:00 [medline]
PHST- 2008/01/22 09:00 [entrez]
AID - JIM1916 [pii]
AID - 10.1111/j.1365-2796.2007.01916.x [doi]
PST - ppublish
SO  - J Intern Med. 2008 Jun;263(6):644-52. doi: 10.1111/j.1365-2796.2007.01916.x. Epub 
      2008 Jan 16.