PMID- 18206543
OWN - NLM
STAT- MEDLINE
DCOM- 20080324
LR  - 20171116
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 180
IP  - 2
DP  - 2008 Jan 15
TI  - Molecular cytogenetic findings in a three-way novel variant of 
      t(1;8;21)(p35;q22;q22): a unique relocation of the AML1/ETO fusion gene 1p35 in 
      AML-M2.
PG  - 153-7
LID - 10.1016/j.cancergencyto.2007.10.005 [doi]
AB  - Acute myeloid leukemia (AML) is a malignant neoplasm of hematopoietic stem cells 
      characterized by an abnormal proliferation of myeloid precursors, a reduced rate 
      of apoptosis, and an arrest in cellular differentiation. The present report deals 
      with the results of hematologic, immunophenotypic, cytogenetic, fluorescence in 
      situ hybridization (FISH), and molecular analyses of a 53-year-old female patient 
      diagnosed with AML-M2. Cytogenetic and FISH analysis revealed a complex 
      translocation involving three chromosomes showing t(1;8;21)(p35;q22;q22). The 
      observation of breakpoints at 8q22 and 21q22 suggests a rearrangement of the ETO 
      and AML1 genes, respectively. Using a dual-color FISH test with ETO and AML1 
      probes, an AML1/ETO fusion signal on the derivative 1p35 instead of der(8) was 
      demonstrated. To the best of our knowledge, this is the first report about the 
      relocation of the AML1/ETO fusion gene to the 1p35 rather than der(8), suggesting 
      the presence of a novel variant of t(8;21)(q22;q22) in the observed patient.
FAU - Ahmad, Firoz
AU  - Ahmad F
AD  - Research and Development, SRL Ranbaxy Ltd., MIDC, Andheri (E), Mumbai-400093, 
      India.
FAU - Kokate, Prajakta
AU  - Kokate P
FAU - Chheda, Pratiksha
AU  - Chheda P
FAU - Dalvi, Rupa
AU  - Dalvi R
FAU - Das, Bibhu Ranjan
AU  - Das BR
FAU - Mandava, Swarna
AU  - Mandava S
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (AML1-ETO fusion protein, human)
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RUNX1 Translocation Partner 1 Protein)
SB  - IM
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 1
MH  - *Chromosomes, Human, Pair 21
MH  - *Chromosomes, Human, Pair 8
MH  - Core Binding Factor Alpha 2 Subunit/*genetics
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Middle Aged
MH  - Oncogene Proteins, Fusion/*genetics
MH  - RUNX1 Translocation Partner 1 Protein
MH  - *Translocation, Genetic
EDAT- 2008/01/22 09:00
MHDA- 2008/03/25 09:00
CRDT- 2008/01/22 09:00
PHST- 2007/09/10 00:00 [received]
PHST- 2007/10/02 00:00 [accepted]
PHST- 2008/01/22 09:00 [pubmed]
PHST- 2008/03/25 09:00 [medline]
PHST- 2008/01/22 09:00 [entrez]
AID - S0165-4608(07)00646-2 [pii]
AID - 10.1016/j.cancergencyto.2007.10.005 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2008 Jan 15;180(2):153-7. doi: 
      10.1016/j.cancergencyto.2007.10.005.