PMID- 18206999
OWN - NLM
STAT- MEDLINE
DCOM- 20080422
LR  - 20131121
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 608
IP  - 1
DP  - 2008 Feb 4
TI  - Development of an on-site screening system for amphetamine-type stimulant tablets 
      with a portable attenuated total reflection Fourier transform infrared 
      spectrometer.
PG  - 95-103
LID - 10.1016/j.aca.2007.12.002 [doi]
AB  - We tried to develop a library search system using a portable, attenuated total 
      reflection Fourier transform infrared (ATR-FT-IR) spectrometer for on-site 
      identification of 3,4-methylenedioxymethamphetamine (MDMA) and 
      3,4-methylenedioxyamphetamine (MDA) tablets. The library consisted of the spectra 
      from mixtures of controlled drugs (e.g. MDMA and ketamine), adulterants (e.g. 
      caffeine), and diluents (e.g. lactose). In the seven library search algorithms, 
      the derivative correlation coefficient showed the best discriminant capability. 
      This was enhanced by segmentation of the search area. The optimized search 
      algorithm was validated by the positive (n=154, e.g. the standard mixtures 
      containing the controlled drug, and the MDMA/MDA tablets confiscated) and 
      negative samples (n=56, e.g. medicinal tablets). All validation samples except 
      for four were judged truly. Final criteria for positive identification were 
      decided on the basis of the results of the validation. In conclusion, a portable 
      ATR-FT-IR spectrometer with our library search system would be a useful tool for 
      on-site identification of amphetamine-type stimulant tablets.
FAU - Tsujikawa, Kenji
AU  - Tsujikawa K
AD  - National Research Institute of Police Science, 6-3-1, Kashiwanoha, Kashiwa, Chiba 
      277-0882, Japan. tujikawa@nrips.go.jp
FAU - Kuwayama, Kenji
AU  - Kuwayama K
FAU - Miyaguchi, Hajime
AU  - Miyaguchi H
FAU - Kanamori, Tatsuyuki
AU  - Kanamori T
FAU - Iwata, Yuko T
AU  - Iwata YT
FAU - Yoshida, Takemi
AU  - Yoshida T
FAU - Inoue, Hiroyuki
AU  - Inoue H
LA  - eng
PT  - Journal Article
DEP - 20071208
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Amphetamines)
RN  - 0 (Tablets)
RN  - 3G6A5W338E (Caffeine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 690G0D6V8H (Ketamine)
RN  - J2B2A4N98G (Lactose)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analysis
MH  - Algorithms
MH  - Amphetamines/*analysis
MH  - Caffeine/analysis
MH  - Chemistry, Pharmaceutical/*methods
MH  - Drug Evaluation, Preclinical
MH  - Equipment Design
MH  - Ketamine/analysis
MH  - Lactose/analysis
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*analysis
MH  - Software
MH  - Spectroscopy, Fourier Transform Infrared/*instrumentation/*methods
MH  - Substance Abuse Detection/*instrumentation/methods
MH  - Tablets
EDAT- 2008/01/22 09:00
MHDA- 2008/04/23 09:00
CRDT- 2008/01/22 09:00
PHST- 2007/07/02 00:00 [received]
PHST- 2007/11/15 00:00 [revised]
PHST- 2007/12/03 00:00 [accepted]
PHST- 2008/01/22 09:00 [pubmed]
PHST- 2008/04/23 09:00 [medline]
PHST- 2008/01/22 09:00 [entrez]
AID - S0003-2670(07)01965-4 [pii]
AID - 10.1016/j.aca.2007.12.002 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2008 Feb 4;608(1):95-103. doi: 10.1016/j.aca.2007.12.002. Epub 
      2007 Dec 8.