PMID- 18207446
OWN - NLM
STAT- MEDLINE
DCOM- 20080620
LR  - 20080310
IS  - 1357-2725 (Print)
IS  - 1357-2725 (Linking)
VI  - 40
IP  - 5
DP  - 2008
TI  - What fires prometheus? The link between inflammation and regeneration following 
      chronic liver injury.
PG  - 855-73
LID - 10.1016/j.biocel.2007.11.025 [doi]
AB  - Liver progenitor cells (LPCs) play a major role in the regeneration process after 
      chronic liver damage, giving rise to hepatocytes and cholangiocytes. Thus, they 
      provide a cell-based therapeutic alternative to organ transplant, the current 
      treatment of choice for end-stage liver disease. In recent years, much attention 
      has focused on unravelling the cytokines and growth factors that underlie this 
      response. Liver regeneration following acute damage is achieved by proliferation 
      of mature hepatocytes; yet similar cytokines, most related to the inflammatory 
      process, are implicated in both acute and chronic liver regeneration. Thus, many 
      recent studies represent attempts to identify LPC-specific factors. This review 
      summarises our current understanding of LPC biology with a particular focus on 
      the liver inflammatory response being associated with the induction of LPCs in 
      the liver. We will describe: (i) the pathways of liver regeneration following 
      acute and chronic damage; (ii) the similarities and differences between the two 
      pathways; (iii) the liver inflammatory environment; (iv) the unique features of 
      liver immunology as well as (v) the interactions between liver immune cells and 
      LPCs. Combining data from studies on the LPC-driven regeneration process with the 
      knowledge in the field of liver immunology will improve our understanding of the 
      LPC response and allow us to regulate these cells in vivo and in vitro for future 
      therapeutic strategies to treat chronic liver disease.
FAU - Viebahn, Cornelia S
AU  - Viebahn CS
AD  - School of Biomedical, Biomolecular and Chemical Sciences, The University of 
      Western Australia, 35 Stirling Highway, M310, Crawley, WA 6009, Australia. 
      viebahn@cyllene.uwa.edu.au
FAU - Yeoh, George C T
AU  - Yeoh GC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20071214
PL  - Netherlands
TA  - Int J Biochem Cell Biol
JT  - The international journal of biochemistry & cell biology
JID - 9508482
RN  - 0 (Cytokines)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
SB  - IM
MH  - Animals
MH  - Chronic Disease
MH  - Cytokines/physiology
MH  - Hepatitis/immunology
MH  - Hepatocytes/metabolism
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/physiology
MH  - Liver/*cytology/*immunology
MH  - Liver Diseases/*immunology
MH  - *Liver Regeneration
MH  - Stem Cells/*physiology
RF  - 112
EDAT- 2008/01/22 09:00
MHDA- 2008/06/21 09:00
CRDT- 2008/01/22 09:00
PHST- 2007/09/27 00:00 [received]
PHST- 2007/11/20 00:00 [revised]
PHST- 2007/11/22 00:00 [accepted]
PHST- 2008/01/22 09:00 [pubmed]
PHST- 2008/06/21 09:00 [medline]
PHST- 2008/01/22 09:00 [entrez]
AID - S1357-2725(07)00392-5 [pii]
AID - 10.1016/j.biocel.2007.11.025 [doi]
PST - ppublish
SO  - Int J Biochem Cell Biol. 2008;40(5):855-73. doi: 10.1016/j.biocel.2007.11.025. 
      Epub 2007 Dec 14.