PMID- 18208542
OWN - NLM
STAT- MEDLINE
DCOM- 20080428
LR  - 20080328
IS  - 1471-4159 (Electronic)
IS  - 0022-3042 (Linking)
VI  - 105
IP  - 1
DP  - 2008 Apr
TI  - BDNF and the diseased nervous system: a delicate balance between adaptive and 
      pathological processes of gene regulation.
PG  - 1-17
LID - 10.1111/j.1471-4159.2008.05237.x [doi]
AB  - It is clear that brain-derived neurotrophic factor (BDNF) plays a crucial role in 
      organizing the response of the genome to dynamic changes in the extracellular 
      environment that enable brain plasticity. BDNF has emerged as one of the most 
      important signaling molecules for the developing nervous system as well as the 
      impaired nervous system, and multiple diseases, such as Alzheimer's, Parkinson's, 
      Huntington's, epilepsy, Rett's syndrome, and psychiatric depression, are linked 
      by their association with potential dysregulation of BDNF-driven signal 
      transduction programs. These programs are responsible for controlling the amount 
      of activated transcription factors, such as cAMP response element binding 
      protein, that coordinate the expression of multiple brain proteins, like ion 
      channels and early growth response factors, whose job is to maintain the balance 
      of excitation and inhibition in the nervous system. In this review, we will 
      explore the evidence for BDNF's role in gene regulation side by side with its 
      potential role in the etiology of neurological diseases. It is hoped that by 
      bringing the datasets together in these diverse fields we can help develop the 
      foundation for future studies aimed at understanding basic principles of gene 
      regulation in the nervous system and how they can be harnessed to develop new 
      therapeutic opportunities.
FAU - Hu, Yinghui
AU  - Hu Y
AD  - Department of Pharmacology and Experimental Therapeutics, Laboratory of 
      Translational Epilepsy, Boston University School of Medicine, Boston, 
      Massachusetts 02118, USA.
FAU - Russek, Shelley J
AU  - Russek SJ
LA  - eng
GR  - R01 NS050393/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20080118
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adaptation, Biological/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Gene Expression Regulation/*physiology
MH  - Humans
MH  - *Nervous System Diseases/genetics/metabolism/pathology
MH  - Neuronal Plasticity/physiology
RF  - 211
EDAT- 2008/01/23 09:00
MHDA- 2008/04/29 09:00
CRDT- 2008/01/23 09:00
PHST- 2008/01/23 09:00 [pubmed]
PHST- 2008/04/29 09:00 [medline]
PHST- 2008/01/23 09:00 [entrez]
AID - JNC5237 [pii]
AID - 10.1111/j.1471-4159.2008.05237.x [doi]
PST - ppublish
SO  - J Neurochem. 2008 Apr;105(1):1-17. doi: 10.1111/j.1471-4159.2008.05237.x. Epub 
      2008 Jan 18.