PMID- 18208585 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20100610 LR - 20211020 IS - 1750-9378 (Electronic) IS - 1750-9378 (Linking) VI - 3 DP - 2008 Jan 21 TI - Insights into pathogenic events of HIV-associated Kaposi sarcoma and immune reconstitution syndrome related Kaposi sarcoma. PG - 1 LID - 10.1186/1750-9378-3-1 [doi] AB - A decrease in the incidence of human immune deficiency virus-associated Kaposi sarcoma (HIV-KS) and regression of some established HIV-KS lesions is evident after the introduction of highly active anti-retroviral treatment (HAART), and is attributed to generalized immune restoration, to the reconstitution of human herpesvirus (HHV)-8 specific cellular immune responses, and to the decrease in HIV Tat protein and HHV-8 loads following HAART. However, a small subset of HIV-seropositive subjects with a low CD4+ T cell count at the time of introduction of HAART, may develop HIV-KS as immune reconstitution inflammatory syndrome (IRIS) within 8 weeks thereafter. FAU - Feller, Liviu AU - Feller L AD - Department of Periodontology and Oral Medicine, Box D26 School of Dentistry, University of Limpopo Medunsa Campus, Pretoria, South Africa. lfeller@medunsa.ac.za FAU - Lemmer, Johan AU - Lemmer J LA - eng PT - Journal Article DEP - 20080121 PL - England TA - Infect Agent Cancer JT - Infectious agents and cancer JID - 101276559 PMC - PMC2265259 EDAT- 2008/01/23 09:00 MHDA- 2008/01/23 09:01 PMCR- 2008/01/21 CRDT- 2008/01/23 09:00 PHST- 2007/11/07 00:00 [received] PHST- 2008/01/21 00:00 [accepted] PHST- 2008/01/23 09:00 [pubmed] PHST- 2008/01/23 09:01 [medline] PHST- 2008/01/23 09:00 [entrez] PHST- 2008/01/21 00:00 [pmc-release] AID - 1750-9378-3-1 [pii] AID - 10.1186/1750-9378-3-1 [doi] PST - epublish SO - Infect Agent Cancer. 2008 Jan 21;3:1. doi: 10.1186/1750-9378-3-1.