PMID- 18208805
OWN - NLM
STAT- MEDLINE
DCOM- 20080311
LR  - 20220309
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 129
IP  - 2
DP  - 2008 Feb
TI  - Epidermal growth factor receptor expression and gene copy number in conventional 
      hepatocellular carcinoma.
PG  - 245-51
LID - 10.1309/WF10QAAED3PP93BH [doi]
AB  - Epidermal growth factor receptor (EGFR) is frequently overexpressed in 
      hepatocellular carcinoma, but its relationship with EGFR gene copy number has not 
      been studied. This study examined EGFR expression and gene copy number in 
      hepatocellular carcinoma and evaluated their relationship to clinicopathologic 
      features in 76 tumors. Moderate to strong expression of EGFR was observed by 
      immunohistochemical analysis in 50 (66%) of 76 hepatocellular carcinomas. 
      Fluorescence in situ hybridization (FISH) showed extra EGFR gene copies in 17 
      (45%) of 38 tumors. This was accompanied by gains of chromosome 7, indicating 
      that this was the result of balanced polysomy rather than gene amplification. 
      There was no correlation between EGFR expression by immunohistochemical analysis 
      and gene copy number by FISH. EGFR expression showed borderline association with 
      cirrhosis but not with other clinicopathologic parameters examined. EGFR 
      overexpression is present in a majority of hepatocellular carcinomas, suggesting 
      a role for EGFR antagonists in therapy. The increased expression does not 
      correlate with an increase in the EGFR gene copy number.
FAU - Buckley, Anne F
AU  - Buckley AF
AD  - Departments of Pathology, UCSF and Veteran Affairs Medical Centers, San 
      Francisco, CA 94121, USA.
FAU - Burgart, Lawrence J
AU  - Burgart LJ
FAU - Sahai, Vaibhav
AU  - Sahai V
FAU - Kakar, Sanjay
AU  - Kakar S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - EC 2.7.10.1 (ErbB Receptors)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Hepatocellular/*genetics/*metabolism
MH  - Child
MH  - Chromosomes, Human, Pair 7
MH  - ErbB Receptors/*metabolism
MH  - Female
MH  - *Gene Dosage
MH  - Gene Expression
MH  - *Genes, erbB-1
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver Neoplasms/*genetics/*metabolism
MH  - Male
MH  - Middle Aged
EDAT- 2008/01/23 09:00
MHDA- 2008/03/12 09:00
CRDT- 2008/01/23 09:00
PHST- 2008/01/23 09:00 [pubmed]
PHST- 2008/03/12 09:00 [medline]
PHST- 2008/01/23 09:00 [entrez]
AID - AX5703N18418625R [pii]
AID - 10.1309/WF10QAAED3PP93BH [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2008 Feb;129(2):245-51. doi: 10.1309/WF10QAAED3PP93BH.