PMID- 18208826
OWN - NLM
STAT- MEDLINE
DCOM- 20081024
LR  - 20201216
IS  - 1468-201X (Electronic)
IS  - 1355-6037 (Linking)
VI  - 94
IP  - 7
DP  - 2008 Jul
TI  - Long-term effects of cardiac resynchronisation therapy in patients with atrial 
      fibrillation.
PG  - 879-83
LID - 10.1136/hrt.2007.129429 [doi]
AB  - OBJECTIVE: To compare the effects of cardiac resynchronisation therapy (CRT) in 
      patients with heart failure (HF) in either atrial fibrillation (AF) or sinus 
      rhythm (SR). DESIGN: Prospective observational study. PATIENTS: 295 consecutive 
      patients with HF (permanent AF in 66, paroxysmal AF in 20, SR in 209; New York 
      Heart Association (NYHA) class III or IV; left ventricular ejection fraction 
      (LVEF) <or=35%, QRS >or=120 ms). INTERVENTIONS: All patients underwent CRT 
      without atrioventricular junction ablation. MAIN OUTCOME MEASURES: The primary 
      end point was the composite of cardiovascular death or unplanned hospitalisation 
      for major cardiovascular events. Secondary end points included the composite of 
      cardiovascular death or hospitalisation for worsening HF. Cardiovascular 
      mortality, total mortality and changes in NYHA class, 6-minute walking distance, 
      quality of life (Minnesota Living with Heart Failure questionnaire) and 
      echocardiographic variables were also considered. RESULTS: Over a follow-up 
      period of up to 6.8 years, no differences emerged between patients in AF or SR in 
      any of the mortality or morbidity end points. The AF and SR groups derived 
      similar improvements in mean NYHA class (-1.3 vs -1.2), 6-minute walking distance 
      (92.3 vs 78.4 m) and quality of life scores (-25.2 vs -18.7) (all p<0.001). In 
      both the AF and the SR groups, reductions were seen in left ventricular 
      end-systolic (-25.9 vs -34.5 ml, both p<0.001) and end-diastolic (-20.2 ml, p = 
      0.001 vs 26.2 ml, p<0.001) volumes and improvements in LVEF (4.69% vs 7.86%, both 
      p<0.001). CONCLUSIONS: Cardiac resynchronisation therapy leads to similar 
      prognostic and symptomatic benefits in patients in AF and SR, even without 
      atrioventricular junction ablation. Echocardiographic improvements are also 
      comparable.
FAU - Khadjooi, K
AU  - Khadjooi K
AD  - Department of Cardiology, Good Hope Hospital, Rectory Road, Sutton Coldfield, 
      West Midlands B75 7RR, UK. cardiologists@hotmail.com
FAU - Foley, P W
AU  - Foley PW
FAU - Chalil, S
AU  - Chalil S
FAU - Anthony, J
AU  - Anthony J
FAU - Smith, R E A
AU  - Smith RE
FAU - Frenneaux, M P
AU  - Frenneaux MP
FAU - Leyva, F
AU  - Leyva F
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
DEP - 20080120
PL  - England
TA  - Heart
JT  - Heart (British Cardiac Society)
JID - 9602087
SB  - IM
CIN - Heart. 2008 Jul;94(7):826-7. PMID: 18552217
CIN - Heart. 2009 Jan;95(1):83; author reply 83-4. PMID: 19047444
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/diagnostic imaging/etiology/physiopathology/*therapy
MH  - Cardiac Pacing, Artificial/*methods
MH  - Disease Progression
MH  - Epidemiologic Methods
MH  - Female
MH  - Heart Failure/complications/diagnostic imaging/physiopathology/*therapy
MH  - Hospitalization
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Stroke Volume
MH  - Treatment Outcome
MH  - Ultrasonography
EDAT- 2008/01/23 09:00
MHDA- 2008/10/25 09:00
CRDT- 2008/01/23 09:00
PHST- 2008/01/23 09:00 [pubmed]
PHST- 2008/10/25 09:00 [medline]
PHST- 2008/01/23 09:00 [entrez]
AID - hrt.2007.129429 [pii]
AID - 10.1136/hrt.2007.129429 [doi]
PST - ppublish
SO  - Heart. 2008 Jul;94(7):879-83. doi: 10.1136/hrt.2007.129429. Epub 2008 Jan 20.