PMID- 18208868
OWN - NLM
STAT- MEDLINE
DCOM- 20081020
LR  - 20171116
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 14
IP  - 4
DP  - 2008 May
TI  - CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI 
      evidence of disease activity in patients with relapsing-remitting multiple 
      sclerosis.
PG  - 446-54
LID - 10.1177/1352458507085137 [doi]
AB  - Cerebrospinal fluid (CSF) concentrations of soluble human leukocyte antigen class 
      I (HLA-I) (sHLA-I), HLA-G (sHLA-G) and anti-apoptotic Fas (sFas) molecules were 
      measured by enzyme linked immunosorbent assay technique in 65 relapsing-remitting 
      (RR) MS patients classified according to clinical and magnetic resonance imaging 
      (MRI) evidence of disease activity. Sixty-four patients with other inflammatory 
      neurological disorders (OIND) and 64 subjects with noninflammatory neurological 
      disorders (NIND) served as controls. CSF concentrations were higher in RRMS and 
      in OIND than in NIND patients for sHLA-I (P < 0.02), greater in RRMS than in OIND 
      and in NIND for sHLA-G (P < 0.001 and P < 0.01, respectively) and lower in RRMS 
      than in OIND and in NIND for sFas (P < 0.001 and P < 0.02, respectively). An 
      increase in CSF levels was identified in MRI active RRMS for sHLA-I (P < 0.01) 
      and in MRI stable RRMS for sHLA-G (P < 0.01), whereas CSF values of sFas were 
      decreased in RRMS without Gd-enhancing lesions (P < 0.02). In MS patients with no 
      evidence of MRI disease activity, a trend towards an inverse correlation was 
      found between CSF concentrations of sHLA-G and sHLA-I and between CSF levels of 
      sHLA-G and sFas. Our results indicate that enhanced CSF levels of sHLA-I antigens 
      most likely represent an indirect manifestation of intrathecal immune activation 
      taking place in neuroinflammation. Conversely, reciprocal fluctuations in CSF 
      sHLA-G and sFas levels observed when MRI disease activity resolved suggest that 
      sHLA-G could play an immunomodulatory role in MS through Fas/FasL-mediated 
      mechanisms.
FAU - Fainardi, E
AU  - Fainardi E
AD  - Multiple Sclerosis Center, Section of Neurology, University of Ferrara, 
      Arcispedale S. Anna, Corso della Giovecca 203, Ferrara I-44100, Italy. 
      henryfai@tin.it
FAU - Rizzo, R
AU  - Rizzo R
FAU - Melchiorri, L
AU  - Melchiorri L
FAU - Stignani, M
AU  - Stignani M
FAU - Castellazzi, M
AU  - Castellazzi M
FAU - Tamborino, C
AU  - Tamborino C
FAU - Paolino, E
AU  - Paolino E
FAU - Tola, M R
AU  - Tola MR
FAU - Granieri, E
AU  - Granieri E
FAU - Baricordi, O R
AU  - Baricordi OR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080121
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (fas Receptor)
SB  - IM
MH  - Adult
MH  - Apoptosis/immunology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - HLA Antigens/*cerebrospinal fluid
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*cerebrospinal fluid
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/*cerebrospinal fluid/*pathology
MH  - Neuritis/cerebrospinal fluid/pathology
MH  - *Severity of Illness Index
MH  - fas Receptor/*cerebrospinal fluid
EDAT- 2008/01/23 09:00
MHDA- 2008/10/22 09:00
CRDT- 2008/01/23 09:00
PHST- 2008/01/23 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2008/01/23 09:00 [entrez]
AID - 1352458507085137 [pii]
AID - 10.1177/1352458507085137 [doi]
PST - ppublish
SO  - Mult Scler. 2008 May;14(4):446-54. doi: 10.1177/1352458507085137. Epub 2008 Jan 
      21.