PMID- 18209723
OWN - NLM
STAT- MEDLINE
DCOM- 20090714
LR  - 20080514
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 41
IP  - 9
DP  - 2008 May
TI  - Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host 
      disease after hematopoietic-cell transplantation.
PG  - 821-6
LID - 10.1038/sj.bmt.1705980 [doi]
AB  - Polymorphisms in cytokine genes can influence immune responses and inflammation 
      and thereby affecting the outcome of hematopoietic stem-cell transplantation. We 
      analyzed a single-nucleotide polymorphism in the gene for the interleukin-23 
      receptor (IL-23R) (1142G>A) in a cohort of 221 transplant recipients and their 
      human leukocyte antigen (HLA)-identical sibling donors and in a second cohort of 
      186 transplant recipients and their HLA-identical unrelated donors. Genotypes 
      were tested for an association with graft-versus-host disease (GVHD) by 
      multivariate analysis. The donor's IL-23R genotype was significantly associated 
      with a reduced risk of acute GVHD in both cohorts for patients after transplant. 
      Analysis of all 407 transplant recipients showed that IL-23R (1142G>A, Arg381Gln) 
      genotype of the donor was associated with a decreased risk of grades 2-4 acute 
      GVHD (31.6 compared to 51.0%, P=0.02) and grades 3-4 severe acute GVHD (3.9 
      compared to 23.4%, P=0.003). Death in remission was significantly lower in 
      patients transplanted from donors with variant IL23-R (11.7 versus 27.7%, 
      P=0.028), whereas overall survival or relapse rates were not influenced 
      significantly by the IL-23R genotype. Among recipients of hematopoietic cells 
      from HLA-identical donors, the IL-23R (Arg381Gln) gene variant on the donor side 
      has a protective effect on the occurrence of acute GVHD in recipients after 
      transplantation.
FAU - Elmaagacli, A H
AU  - Elmaagacli AH
AD  - Department of Bone Marrow Transplantation, University Hospital of Essen, Essen, 
      Germany. ahmet.elmaagacli@uni-duisburg.essen.de
FAU - Koldehoff, M
AU  - Koldehoff M
FAU - Landt, O
AU  - Landt O
FAU - Beelen, D W
AU  - Beelen DW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20080121
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
RN  - 0 (IL23R protein, human)
RN  - 0 (Receptors, Interleukin)
SB  - IM
MH  - Acute Disease
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Child
MH  - Disease-Free Survival
MH  - Female
MH  - Genotype
MH  - Graft vs Host Disease/*genetics/mortality
MH  - HLA Antigens/genetics
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - *Living Donors
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Receptors, Interleukin/*genetics
MH  - Risk Factors
MH  - Siblings
MH  - Survival Rate
EDAT- 2008/01/23 09:00
MHDA- 2009/07/15 09:00
CRDT- 2008/01/23 09:00
PHST- 2008/01/23 09:00 [pubmed]
PHST- 2009/07/15 09:00 [medline]
PHST- 2008/01/23 09:00 [entrez]
AID - 1705980 [pii]
AID - 10.1038/sj.bmt.1705980 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2008 May;41(9):821-6. doi: 10.1038/sj.bmt.1705980. Epub 
      2008 Jan 21.