PMID- 18210813
OWN - NLM
STAT- MEDLINE
DCOM- 20080404
LR  - 20091119
IS  - 0009-918X (Print)
IS  - 0009-918X (Linking)
VI  - 47
IP  - 11
DP  - 2007 Nov
TI  - [Pathogenic mechanisms of myasthenia gravis induced by antibodies against 
      muscle-specific kinase].
PG  - 842-4
AB  - Antibodies to acetylcholine receptor (AChR) are major cause of the human 
      autoimmune disease, myasthenia gravis (MG). Additionally, autoantibodies against 
      Muscle-specific kinase (MuSK) were found in a proportion of patients with 
      generalized MG. After the identification of MuSK antibodies in MG patients, 
      laboratory test for measuring antibodies to MuSK is now required to confirm the 
      diagnosis of MG and the clinical treatment as well as AChR antibodies. MuSK is 
      critical to the clustering of AChR and plays multiple roles at neuromuscular 
      junctions (NMJ). However, it has been dispute concerning the pathogenicity of 
      MuSK antibodies in muscle weakness of MG, as the experimental autoimmune MG 
      caused by MuSK antibodies was absent. Here we describe the recent progress to 
      understand the pathogenic roles of MuSK antibodies in muscle weakness of 
      experimental animals induced by MuSK protein.
FAU - Maruyama, Naoki
AU  - Maruyama N
AD  - Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
FAU - Shigemoto, Kazuhiro
AU  - Shigemoto K
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Rinsho Shinkeigaku
JT  - Rinsho shinkeigaku = Clinical neurology
JID - 0417466
RN  - 0 (Autoantibodies)
RN  - 0 (Receptors, Cholinergic)
RN  - EC 2.7.10.1 (MUSK protein, human)
RN  - EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Autoantibodies/*immunology
MH  - Disease Models, Animal
MH  - Humans
MH  - Myasthenia Gravis, Autoimmune, Experimental/*immunology
MH  - Rabbits
MH  - Receptor Protein-Tyrosine Kinases/*immunology
MH  - Receptors, Cholinergic/*immunology
EDAT- 2008/01/24 09:00
MHDA- 2008/04/05 09:00
CRDT- 2008/01/24 09:00
PHST- 2008/01/24 09:00 [pubmed]
PHST- 2008/04/05 09:00 [medline]
PHST- 2008/01/24 09:00 [entrez]
PST - ppublish
SO  - Rinsho Shinkeigaku. 2007 Nov;47(11):842-4.