PMID- 1821150
OWN - NLM
STAT- MEDLINE
DCOM- 19920820
LR  - 20190815
IS  - 0731-7085 (Print)
IS  - 0731-7085 (Linking)
VI  - 9
IP  - 9
DP  - 1991
TI  - Liquid chromatographic determination of amoxycillin and clavulanic acid in 
      pharmaceutical preparations.
PG  - 731-5
AB  - A liquid chromatographic method for the simultaneous determination of amoxycillin 
      and potassium clavulanate in tablet and suspension preparations is presented. The 
      method specifies reversed phase column and a buffered mobile phase (CH3OH + 
      KH2PO4-buffer pH 6 + H2O, 15:1:84) isocratically at a rate of 1.0 ml min-1, with 
      detection at 235 nm. The suitability of the chromatographic system developed is 
      tested using replicate injections of the sample and standard preparations. The 
      observed relative standard deviations (RSDs) were within 2%. Recovery experiments 
      conducted utilizing the proposed method gives results of 101.5% +/- 1.72 (n = 6) 
      and 101.22% +/- 1.93 (n = 6) for amoxycillin in tablets and powder for oral 
      administration, respectively. Similarly, recovery experiments for clavulanic acid 
      gave results of 100.33 +/- 1.90 (n = 6) and 99.61 +/- 1.32 (n = 6) in the tablets 
      and suspension powder, respectively. Comparison of the proposed method with the 
      USP method proved it to be satisfactory. The statistical F- and t-tests observed, 
      indicated that there were no significant differences between the two methods 
      regarding precision and accuracy.
FAU - Abounassif, M A
AU  - Abounassif MA
AD  - Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud 
      University, Riyadh, Saudi Arabia.
FAU - Abdel-Moety, E M
AU  - Abdel-Moety EM
FAU - Mohamed, M E
AU  - Mohamed ME
FAU - Gad-Kariem, R A
AU  - Gad-Kariem RA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - J Pharm Biomed Anal
JT  - Journal of pharmaceutical and biomedical analysis
JID - 8309336
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Clavulanic Acids)
RN  - 0 (Powders)
RN  - 0 (Tablets)
RN  - 23521W1S24 (Clavulanic Acid)
RN  - 804826J2HU (Amoxicillin)
SB  - IM
MH  - Amoxicillin/*analysis
MH  - Anti-Bacterial Agents/*analysis
MH  - Chromatography, Liquid/methods
MH  - Clavulanic Acid
MH  - Clavulanic Acids/*analysis
MH  - Powders/analysis
MH  - Tablets/analysis
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 0731-7085(91)80214-T [pii]
AID - 10.1016/0731-7085(91)80214-t [doi]
PST - ppublish
SO  - J Pharm Biomed Anal. 1991;9(9):731-5. doi: 10.1016/0731-7085(91)80214-t.