PMID- 18211710
OWN - NLM
STAT- MEDLINE
DCOM- 20080702
LR  - 20240211
IS  - 1471-2172 (Electronic)
IS  - 1471-2172 (Linking)
VI  - 9
DP  - 2008 Jan 22
TI  - HLA class I supertypes: a revised and updated classification.
PG  - 1
LID - 10.1186/1471-2172-9-1 [doi]
AB  - BACKGROUND: Class I major histocompatibility complex (MHC) molecules bind, and 
      present to T cells, short peptides derived from intracellular processing of 
      proteins. The peptide repertoire of a specific molecule is to a large extent 
      determined by the molecular structure accommodating so-called main anchor 
      positions of the presented peptide. These receptors are extremely polymorphic, 
      and much of the polymorphism influences the peptide-binding repertoire. However, 
      despite this polymorphism, class I molecules can be clustered into sets of 
      molecules that bind largely overlapping peptide repertoires. Almost a decade ago 
      we introduced this concept of clustering human leukocyte antigen (HLA) alleles 
      and defined nine different groups, denominated as supertypes, on the basis of 
      their main anchor specificity. The utility of this original supertype 
      classification, as well several other subsequent arrangements derived by others, 
      has been demonstrated in a large number of epitope identification studies. 
      RESULTS: Following our original approach, in the present report we provide an 
      updated classification of HLA-A and -B class I alleles into supertypes. The 
      present analysis incorporates the large amount of class I MHC binding data and 
      sequence information that has become available in the last decade. As a result, 
      over 80% of the 945 different HLA-A and -B alleles examined to date can be 
      assigned to one of the original nine supertypes. A few alleles are expected to be 
      associated with repertoires that overlap multiple supertypes. Interestingly, the 
      current analysis did not identify any additional supertype specificities. 
      CONCLUSION: As a result of this updated analysis, HLA supertype associations have 
      been defined for over 750 different HLA-A and -B alleles. This information is 
      expected to facilitate epitope identification and vaccine design studies, as well 
      as investigations into disease association and correlates of immunity. In 
      addition, the approach utilized has been made more transparent, allowing others 
      to utilize the classification approach going forward.
FAU - Sidney, John
AU  - Sidney J
AD  - Division of Vaccine Discovery, The La Jolla Institute for Allergy and Immunology, 
      9420 Athena Circle, La Jolla, CA 92037, USA. jsidney@liai.org
FAU - Peters, Bjoern
AU  - Peters B
FAU - Frahm, Nicole
AU  - Frahm N
FAU - Brander, Christian
AU  - Brander C
FAU - Sette, Alessandro
AU  - Sette A
LA  - eng
GR  - N01AI40023/AI/NIAID NIH HHS/United States
GR  - N01AI40024/AI/NIAID NIH HHS/United States
GR  - N01-AI-40024/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20080122
PL  - England
TA  - BMC Immunol
JT  - BMC immunology
JID - 100966980
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunodominant Epitopes)
SB  - IM
MH  - Alleles
MH  - Amino Acid Motifs/immunology
MH  - Antigen Presentation
MH  - Binding Sites/immunology
MH  - Epitopes
MH  - Histocompatibility Antigens Class 
      I/*classification/genetics/immunology/metabolism
MH  - Histocompatibility Testing/trends
MH  - Humans
MH  - Immunodominant Epitopes/genetics/*immunology/metabolism
MH  - Protein Binding
MH  - Sequence Analysis, Protein
PMC - PMC2245908
EDAT- 2008/01/24 09:00
MHDA- 2008/07/03 09:00
PMCR- 2008/01/22
CRDT- 2008/01/24 09:00
PHST- 2007/07/13 00:00 [received]
PHST- 2008/01/22 00:00 [accepted]
PHST- 2008/01/24 09:00 [pubmed]
PHST- 2008/07/03 09:00 [medline]
PHST- 2008/01/24 09:00 [entrez]
PHST- 2008/01/22 00:00 [pmc-release]
AID - 1471-2172-9-1 [pii]
AID - 10.1186/1471-2172-9-1 [doi]
PST - epublish
SO  - BMC Immunol. 2008 Jan 22;9:1. doi: 10.1186/1471-2172-9-1.