PMID- 18215008
OWN - NLM
STAT- MEDLINE
DCOM- 20080408
LR  - 20191210
IS  - 0951-4198 (Print)
IS  - 0951-4198 (Linking)
VI  - 22
IP  - 4
DP  - 2008
TI  - Determination of D/L-amino acids by zero needle voltage electrospray ionisation.
PG  - 455-61
LID - 10.1002/rcm.3384 [doi]
AB  - Ion formation may be made more efficient than in normal electrospray ionization 
      (ESI) for certain classes of compounds, such as the polar amino acids Glu, Asn, 
      His, Ser, Asp, Arg, Tyr and Lys, by adjusting the voltage of a normal ESI 
      interface needle to zero voltage. For aspartic acid (Asp) the gain in 
      signal-to-noise (S/N) ratio of the liquid chromatography/mass spectrometry 
      (LC/MS) chromatograms obtained in the selective ion monitoring (SIM) mode (m/z 
      134) with zero needle potential was 40-50 times higher than detection at 4 kV. 
      Ion formation at zero potential is likely to follow a mechanism related to sonic 
      spray ionization. The utility of the zero needle voltage ESI was illustrated by 
      determining the age of a human tooth by the aspartic acid epimerization method. 
      The procedure involved separating the D- and L-aspartic acid of a tooth extract 
      on a chiral HPLC column and detection by zero voltage ESI-MS3.
FAU - Sorensen, Morten B
AU  - Sorensen MB
AD  - Department of Nature, Systems and Models, Roskilde University, DK-4000 Roskilde, 
      Denmark.
FAU - Aaslo, Per
AU  - Aaslo P
FAU - Egsgaard, Helge
AU  - Egsgaard H
FAU - Lund, Torben
AU  - Lund T
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - England
TA  - Rapid Commun Mass Spectrom
JT  - Rapid communications in mass spectrometry : RCM
JID - 8802365
RN  - 0 (Amino Acids)
SB  - IM
MH  - Age Determination by Teeth/*methods
MH  - Amino Acids/*analysis/*chemistry
MH  - Electrochemistry/*methods
MH  - Forensic Dentistry/*methods
MH  - Humans
MH  - In Vitro Techniques
MH  - Isomerism
MH  - Needles
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Spectrometry, Mass, Electrospray Ionization/*methods
MH  - Tooth/*chemistry
EDAT- 2008/01/25 09:00
MHDA- 2008/04/09 09:00
CRDT- 2008/01/25 09:00
PHST- 2008/01/25 09:00 [pubmed]
PHST- 2008/04/09 09:00 [medline]
PHST- 2008/01/25 09:00 [entrez]
AID - 10.1002/rcm.3384 [doi]
PST - ppublish
SO  - Rapid Commun Mass Spectrom. 2008;22(4):455-61. doi: 10.1002/rcm.3384.