PMID- 18219259
OWN - NLM
STAT- MEDLINE
DCOM- 20080502
LR  - 20220331
IS  - 0022-3069 (Print)
IS  - 0022-3069 (Linking)
VI  - 67
IP  - 2
DP  - 2008 Feb
TI  - Enhancement of cutaneous nerve regeneration by 4-methylcatechol in 
      resiniferatoxin-induced neuropathy.
PG  - 93-104
LID - 10.1097/nen.0b013e3181630bb8 [doi]
AB  - To generate an experimental neuropathy model in which small-diameter sensory 
      nerves are specifically affected and to test a potential treatment, adult mice 
      were given a single injection (50 microg/kg, i.p.) of the capsaicin analog 
      resiniferatoxin (RTX). On Day 7 after RTX treatment, there was a 53% reduction in 
      unmyelinated nerve density in the medial plantar nerve (p = 0.0067) and a 66% 
      reduction in epidermal nerve density of hind paw skin (p = 0.0004) compared with 
      vehicle-treated controls. Substance P-immunoreactive dorsal root ganglion neurons 
      were also markedly depleted (p = 0.0001). These effects were associated with the 
      functional deficit of prolonged withdrawal latencies to heat stimuli (p = 0.0007) 
      on a hot plate test. The potential therapeutic effects of 4-methylcatechol (4MC) 
      on this neuropathy were then tested by daily injections of 4MC (10 microg/kg, 
      i.p.) from Days 7 to 35 after neuropathy induction. On Day 35, 4MC-treated mice 
      had an increase in unmyelinated (p = 0.014) and epidermal nerve (p = 0.0013) 
      densities and a reduction in thermal withdrawal latency (p = 0.0091) compared 
      with RTX-only controls. These results indicate that 4MC promoted regeneration of 
      unmyelinated nerves in experimental RTX-induced neuropathy and enhanced function.
FAU - Hsieh, Yu-Lin
AU  - Hsieh YL
AD  - Department of Anatomy and Cell Biology, National Taiwan University College of 
      Medicine, National Taiwan University Hospital, Taipei, Taiwan.
FAU - Chiang, Hao
AU  - Chiang H
FAU - Tseng, To-Jung
AU  - Tseng TJ
FAU - Hsieh, Sung-Tsang
AU  - Hsieh ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neuropathol Exp Neurol
JT  - Journal of neuropathology and experimental neurology
JID - 2985192R
RN  - 0 (Catechols)
RN  - 0 (Diterpenes)
RN  - 0 (Neuroprotective Agents)
RN  - 12GLI7JGB3 (4-methylcatechol)
RN  - 33507-63-0 (Substance P)
RN  - A5O6P1UL4I (resiniferatoxin)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
RN  - EC 3.4.19.12 (Uchl1 protein, mouse)
RN  - JHB2QIZ69Z (Calcitonin Gene-Related Peptide)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Animals
MH  - Calcitonin Gene-Related Peptide/metabolism
MH  - Capsaicin
MH  - Catechols/*therapeutic use
MH  - Disease Models, Animal
MH  - *Diterpenes
MH  - Drug Interactions
MH  - Ganglia, Spinal/metabolism
MH  - Hyperalgesia/drug therapy
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Nerve Fibers, Unmyelinated/drug effects/pathology/ultrastructure
MH  - Nerve Regeneration/*drug effects/physiology
MH  - Neural Conduction/drug effects
MH  - Neuroprotective Agents/*therapeutic use
MH  - *Peripheral Nervous System Diseases/chemically induced/drug 
      therapy/physiopathology
MH  - Reaction Time/drug effects
MH  - Skin/*innervation
MH  - Substance P/metabolism
MH  - Ubiquitin Thiolesterase/metabolism
EDAT- 2008/01/26 09:00
MHDA- 2008/05/03 09:00
CRDT- 2008/01/26 09:00
PHST- 2008/01/26 09:00 [pubmed]
PHST- 2008/05/03 09:00 [medline]
PHST- 2008/01/26 09:00 [entrez]
AID - 10.1097/nen.0b013e3181630bb8 [doi]
PST - ppublish
SO  - J Neuropathol Exp Neurol. 2008 Feb;67(2):93-104. doi: 
      10.1097/nen.0b013e3181630bb8.